Long-term survival of living donor renal transplants: A single center study
J Hassanzadeh1, AA Hashiani2, A Rajaeefard1, H Salahi3, E Khedmati4, F Kakaei5, S Nikeghbalian3, A Malek-Hossein3
1 Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
2 Faculty of Health, Arak University of Medical Sciences, Arak, Iran
3 Shiraz Organ Transplantation Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
5 Department of Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
|Date of Web Publication||1-Dec-2010|
A A Hashiani
School of Health, Arak University of Medical Sciences, Arak
Source of Support: None, Conflict of Interest: None
Kidney transplantation is the treatment of choice for end-stage renal disease. The aim of this study was to determine the ten-year graft survival rate of renal transplantation in patients who have been transplanted from live donors. This is a historical cohort study designed to determine the organ survival rate after kidney transplantation from live donor during a 10-year period (from March 1999 to March 2009) on 843 patients receiving kidney transplant in the transplantation center of Namazi hospital in Shiraz, Iran. Kaplan-Meier method was used to determine the survival rate, log-rank test was used to compare survival curves, and Cox proportional hazard model was used to multivariate analysis. Mean follow-up was 53.07 ± 34.61 months. Allograft survival rates at 1, 3, 5, 7, and 10 years were 98.3, 96.4, 92.5, 90.8, and 89.2%, respectively. Using Cox proportional hazard model, the age and gender of the donors along with the creatinine level of the patients at discharge were shown to have a significant influence on survival. The 10-year graft survival rate of renal transplantation from living donor in this center is 89.2%, and graft survival rate in our cohort is satisfactory and comparable with reports from large centers in the world.
Keywords: Cox proportional hazard model, graft survival rate, living donor, renal transplantation
|How to cite this article:|
Hassanzadeh J, Hashiani A A, Rajaeefard A, Salahi H, Khedmati E, Kakaei F, Nikeghbalian S, Malek-Hossein A. Long-term survival of living donor renal transplants: A single center study. Indian J Nephrol 2010;20:179-84
|How to cite this URL:|
Hassanzadeh J, Hashiani A A, Rajaeefard A, Salahi H, Khedmati E, Kakaei F, Nikeghbalian S, Malek-Hossein A. Long-term survival of living donor renal transplants: A single center study. Indian J Nephrol [serial online] 2010 [cited 2019 Sep 20];20:179-84. Available from: http://www.indianjnephrol.org/text.asp?2010/20/4/179/73439
| Introduction|| |
Chronic kidney disease (CKD) is a public health concern, imposing heavy financial burden to the society.  According to the data obtained from 'Management Center for Transplantation and Special Diseases,' number of end-stage renal disease (ESRD) patients under renal replacement therapy in Iran (population = 70 million) was about 25 000 in 2006. Considering an annual growth rate of 12%, that number can reach 40 000 year 2011. The prevalence and incidence rate of ESRD in Iran have reported to be 357 and 57 cases per million populations per year, respectively.  During recent years, need for renal replacement therapy has been increased in the entire world including Iran.  Most of these patients are treated by hemodialysis, peritoneal dialysis, and renal transplantation ,,, Renal transplantation is the best choice for treatment of the ESRD, ,,,,,,,, and transplanted patients experience better survival rate and quality of life. , The first kidney transplantation in Iran was performed in 1967 in Shiraz. , The rate of renal transplantation in Iran has exceeded around 24 cases per every million persons in the recent years.  Deceased-donor transplantation is an important organ source,  but the survival rate of living donor transplantation is higher. ,, This study was designed to determine 10-year survival rate in patient with living donor transplantation in Shiraz transplant center, Namazi hospital, Shiraz, Iran, from January 1999 till December 2009.
| Materials and Methods|| |
Our study is a survival rate analysis; subjects consist of all recipients of living donor kidney transplantation between January 1999 and December 2009. This center performed 1355 cases of kidney transplantation of which 843 were from living donors. As a rule, we do not use donors whose last preoperative serum creatinine level was over 1.4 mg/dl or last 24-hour urine output was less than 1 ml/kg/h. We have not been performing preoperative donor conventional or computed tomography (CT) angiography during the last 6 years of this period, and duplex ultrasonography and intravenous pyelography are the only imaging studies of the renal system of the donors that we use. CT angiography is used only when the duplex ultrasonography suggests any abnormal findings in renal vasculature. This selective use of contrast imaging studies prevents the use of excessive doses of intravenous contrast agents which may be toxic for the donor kidneys, and warrants the safety of the donor surgery and picks up an occasional donor with renovascular pathology. We prefer left kidney because of longer renal vein and better accessibility for nephrectomy, and use the right kidney only in special situations.
Intravenous methylprednisolone was used for induction immunosuppressive regimen for all patients, except for special patients such as those with previous graft failure due to rejection, second transplantation, or those with panel reactive antibody over 20% in which cases the methylprednisolone were replaced by basiliximab, daclizumab, or antithymocyte globulin, according to nephrologists' preferences. Four different regimens had been prescribed to recipients for maintenance therapy:
The exact time of transplantation was considered to be the 'initial event,' and irreversible loss of renal allograft (when the patient needs regular dialysis again) was defined as 'end-point event.' Cases, who did not encounter the end point event because of death from any other cause or those who were loss to follow-up, have been censored.
- Oral prednisolone, azathioprine (Imuran® ), and cyclosporine (Neoral® ).
- Oral prednisolone, mycophenolate mofetil (Cellcept® ), and cyclosporine (Neoral® ).
- Oral prednisolone, azathioprine which was changed to mycophenolate mofetil (Cellcept® ) after different time intervals, and cyclosporine (Neoral® ).
- Oral prednisolone, mycophenolate mofetil (Cellcept® ), and tacrolimus (Prograf® ).
Data were collected through review of hospital and transplant clinic records. The organ survival and return to regular dialysis were assessed and determined by nephrologists and recorded in follow-up records of transplant clinics and related institutions such as 'Management Center for Transplantation and Special Diseases' and 'Renal Patients Support Society.'
For analyzing survival rate, Kaplan-Meier method and for comparing survival curves Log-rank test were applied. Data modeling was done by applying Cox regression model and for evaluating assumption of hazard ratio proportionality (AHRP) (as one of the Cox model assumptions), two graphic models (i.e., plotting curve of Log (-log (t)) on log (t) and observed curve accompanied with predicted curve) and goodness of fit method were used.
Survival data were analyzed by running SPSS software, version 16 (SPSS Inc., Chicago, IL) and for evaluation of AHRP, Intercooled STATA 9 has been used.
| Results|| |
As shown in [Table 1], 61.4% of donors and 68.7% of recipients were males. About 52% of donors were nonrelated living donors and 39% were brothers or sisters of the recipient. Blood group O made up 52% and 42.4% of donors and recipients' blood group, respectively. 82.9% of donors and recipients were of the same blood group.
|Table 1: Distribution of demographic, surgical and medical variables in study|
Click here to view
In more than 50% of cases, underlying causes were not known. In 398 cases, the cause of disease was known, 103 cases (25.9%) of them were because of glomerulonephritis. Cold ischemia time was less than 1 hour in most of the cases. The mean age of the donors and recipients was 32.7 ± 8.6 and 35.2 ± 13.4 years, respectively. The duration of hospitalization after transplantation, duration of dialysis before transplant, and creatinine level at discharge were 12.2 ± 5.2 days, 14.2 ± 13.3 months, and 1.6 ± 1.1 mg/dl, respectively. 0.8% of recipients were HCV positive. 94.7% of recipients had urine production immediately after vascular declamping. In 98% of the procedures, the left kidney was used. Vascular complications were seen in 7.3% of all study patients. The most frequent vascular complications were hemorrhage seen in 5.2% of the cases followed by renal artery stenosis in 1.18%, renal artery thrombosis in 0.23%, and renal vein thrombosis in 0.35% of the patients. Of 843 patients, 5% were lost to follow-up. Of the remaining, 48 (5.7%) had irreversible transplant rejection. Mean duration of follow-up in this study was 53.07 ± 34.61 months.
As shown in [Figure 1], allograft survival rates at 1, 3, 5, 7, and 10 years after kidney transplantation were 98.3 ± 0.5, 96.4 ± 0.7, 92.5 ± 1.2, 90.8 ± 1.4, and 89.2 ± 1.8%, respectively.
|Figure 1: Allograft survival rate in renal transplant recipients from living donor|
Click here to view
Univariate analysis showed that graft survival rate in our series has not been significantly different in terms of the following factors: recipient's place of residence, similarity of blood group, being HCV positive, sex of recipient, sexual mismatch of donors and recipients, age of recipient, type of immunosuppressive maintenance regimen, cause of ESRD, side of the donor graft, type of donor (related or unrelated), cold ischemia time, relationship of donor and recipient, time of first urination after vascular declamping, duration of dialysis before operation, and duration of hospitalization after surgery; whereas, blood group of donor ( P = 0.02) and recipient ( P = 0.015), sex of donor ( P = 0.02), age of donor ( P = 0.014), and creatinine level at discharge ( P = 0.001) were significantly associated with graft survival.
Testing the AHRP using goodness of fit method showed that this assumption was true for variables. Graphic methods have been done for assessing this assumption for all variables, but because of space limitations of this article, these methods have been shown only for variables of donor's age [Figure 2] and donor's sex [Figure 3] as examples.
|Figure 2: Testing of proportionality of hazard ratio assumption using the method of curve of Log (-log (t)) on log (t) based on donor's age|
Click here to view
|Figure 3: Assessment of proportionality of hazard ratio assumption using the method of predicted and observed values based on donor's sex|
Click here to view
For modeling, those variables with P values less than 0.25 in univariate analysis and reasonable AHRP were entered into Cox proportional hazard model in a Forward stepwise manner. Results of Cox proportional hazard model have been shown in [Table 2]. The hazard ratio (HR) for female donors in comparison with males was 2.57 ( P = 0.017, 95% confidence interval [CI] for HR = 1.18-5.4), and HR for over 40-year-old donors compared to those less than 40-year-old was 2.49 ( P = 0.012, 95% CI = 1.22-5.06). Also, HR for creatinine level at discharge over 2 mg/dl was 4.9 ( P = 0.001, 95% CI =2.17-10.5).
| Discussion|| |
Thanks to progresses in surgical techniques and novel immunosuppressive drugs, the survival rate of transplantation has risen stunningly compared with past decades. According to the results of this study, 1-, 3-, 5-, 7-, and 10-year survival rates of renal transplantation in our center have been 98.3, 96.4, 92.5, 90.8, and 89.2%, respectively, whereas in this center and in the same period, allograft survival rates at 1, 3, 5, and 9 years after kidney transplantation from deceased donor was found to be 93.7, 89.1, 82.1, and 80.1%, respectively. 
Based on the previous reports of Iran organ procurement network,  nationwide one-year survival rate of renal transplantation is about 94.7% in Iran, and our study shows that this rate is slightly higher in our center.
Plenty of studies have shown that there is no significant relationship between sex of recipient and donor and survival rate of transplantation. ,, In our study, there was no significant relationship between sex of recipient and survival rate, but male donors there has statistically better graft survival rates.
According to our findings, there was no significant difference between graft survival from donors and recipients with same blood group with donors and recipients with compatible blood group. This finding is supported by some other studies, , but Park et al.  have showed that those with same blood group had better rates of survival in comparison to those with different blood groups.
Several studies , reported that rise of cold ischemia time leads to reduction of transplant survival rate significantly, but in a study done by Courtney et al.  there was no significant relationship between cold ischemia time and survival rate, a result which is similar with our study. One of the reasons for differences in results can emanate from defect in registering precise duration of cold ischemia time in our study, as just in 35% this time was known. In those with reported cold ischemia time, this time was less than 1 hour in most of the patients. These problems might affect the statistical power of the study.
Presence of HCV infection and its relationship with renal transplantation survival rate is still controversial. In some studies, graft and patient survival in HCV positives and negatives recepients have been reported to be equal. ,
On the other hand, some studies have evidenced higher rates of survival in HCV negative subjects. ,
From this point of view, our study also showed that there was no significant relationship between these two variables. But again, this conclusion may be due to low number (less than 1%) of HCV positive patients in our study group.
Courtney et al.  have shown that underlying cause of ESRD may affect renal transplantation survival rate. But some other studies did not report such a relationship. ,, There was no significant difference between transplantation survival rate and primary renal disease in our study, but it should be mentioned that in our study there was no known underlying reason for ESRD in half of our patients, because most of them referred for CKD evaluation with small nonfunctional kidneys without any known underlying disease, and diagnosing the cause in this group is almost impossible in most cases.
In our study, time of dialysis prior to renal transplantation had no significant relationship with survival rate, whereas some other studies , revealed that longer time on dialysis prior to transplantation is an independent predictor of worse graft survival rate.
In this study, the side of retrieved donor's kidney has no significant effect on survival rate. As previously mentioned, in our center, we do not perform any angiographic evaluation of the donors and prefer to use left kidney of living donors because of having longer vein in comparison with right one. Because of low number of right kidneys, we could not rely on the statistical analysis of this factor.
Creatinine level at the time of discharge had a significant relationship with survival rate. In a study done by Rayhill et al., creatinine level at the time of discharge had significant relationship with renal transplant survival rate, with every 1mg/dl increase in creatinine level, HR of graft loss increases 1.8 unit. 
In recent decades, progresses in immunosuppressive regimes have led to increase in survival rate. First studies on drugs ,,, indicated that mycophenolate, despite increasing expense, can reduce the acute graft rejection rate in comparison with azathioprine. But in recent studies, observed results have not shown any difference between these two drugs in terms of acute graft rejection, transplant survival rate, and patient survival.  Also, some studies have shown that there was no relationship between type of maintenance immunosuppressive drugs and survival rate , ; this finding is confirmed in our study.
Our study findings showed that donor age was affect graft survival, partly because of the reduction of nephron mass in older donors, but like other studies, , our study also did not show any significant relationship between age of recipient and survival rate.
Because of the lack of financial support we are not able to perform routine human leukocyte antigen typing in our recipients and also the acute rejection episodes after the first 3 months of operation are treated in nephrology wards (not transplant ward), and the data about these episodes are not complete. Therefore, we could not enumerate the effect of these variables on long-term survival of the graft.
| Conclusion|| |
The 10-year graft survival rate of renal transplantation from living donor in this center is 89.2%, and graft survival rate in our cohort is satisfactory and similar to reports from large centers in the world. Findings of this study showed that graft survival was higher in donors younger than 40 years, male donors, and creatinine level less than 2 mg/dl at discharge.
| References|| |
|1.||Bosan IB. Recommendation for early diagnosis of chronic kidney disease. Ann Afr Med 2007;6:130-6. |
|2.||Abbaszadeh S, Nourbala MH, Taheri S, Ashraf A, Einollahi B. Renal transplantation from deceased donor in Iran. Saudi J Kidney Dis Transpl 2008;19:664-8. |
|3.||Abboud O. Incidence, prevalence and treatment of end stage renal disease in the Middle East. Ethn Dis 2006;16:S2-2-S2-4. |
|4.||Mahdavi-Mazdeh M, Heidary Rouchi A, Norouzi S, Aghighi M, Rajolani H, Ahrabi S. Renal Replacement therapy in Iran. Urol J 2007;4:66-70. |
|5.||Schena FP. Epidemiology of end stage renal disease: international comparisons of renal replacement therapy. Kidney Int 2000;57:39-45. |
|6.||Hashiani AA, Rajaeefard A, Hassanzade J, Kakaei F, Behbahan AG, Nikeghbalian S, et al. Ten-year graft survival of deceased-donor kidney transplantation: A single-center experience. Ren Fail 2010;32:440-7. |
|7.||Hariharan S, Johnson CP, Bresnahan BA, Taranto SE, McIntosh MJ, Stablein D. Improved graft survival after renal transplantation in the United States, 1988 to 1996. N Engl J Med 2000;342:605-12. |
|8.||Cacho DT, Cusν LI, Piquι AA, Villar PB, Reyes LI, Alvarez-Vijande Garcνa R, Elderly donor kidney transplant: factors involved in graft survival. Transplant Proc 2005;37:3690-992. |
|9.||Sumboonnanonda A, Lumpaopong A, Kingwatanakul P, Tangnararatchakit K, Jiravuttipong A. Pediatric kidney transplantation in Thailand: Experience in a developing country. Transplant Proc 2008;40:2271-3. |
|10.||Nemati E, Pourfarziani V, Jafari AM, Assari S, Moghani-Lankarani M, Khedmat H, et al. Prediction of inpatient survival and graft loss in rehospitalized kidney recipients. Transplant Proc 2007;39:974-7. |
|11.||Parada B, Figueiredo A, Nunes P, Bastos C, Macario F, et al. Pediatric renal transplantation: comparative study with renal transplantation in the adult population. Transplant Proc 2005;37:2771-4. |
|12.||Salehipour M, Salahi H, Jalaeian H, Bahador A, Nikeghbalian S, Barzideh E, et al. Vascular complication following 1500 consecutive living and cadaveric donor renal transplantation: A single center study. Saudi J Kidney Dis Transpl 2009;20:570-2. |
|13.||Col PP Varma, Col AK Hooda, Col T Sinha, et al. Renal transplantation: An experience of 500 patients. Medical journal Armed Forced India 2007;63:107-11. |
|14.||Einollahi B. Iranian experience with the non-related renal transplantation. Saudi J Kidney Dis Transpl 2004;15:421-8. |
|15.||Meier-Kriesche HU, Port FK, Ojo AO, Rudich SM, Hanson JA, Cibrik DM, et al. Effect of waiting time on renal transplant out come. Kidney Int 2000;58:1311-7. |
|16.||Shrestha BM, Haylor JL. Factors influencing long term outcome following renal transplantation: A review. J Nepal Med Assoc 2007;46:136-42. |
|17.||Ghods AJ. Renal transplantation in Iran. Nephrol Dial transplant 2002;17:222-8. |
|18.||Tan SY, Chen TP, Lee SH, Tan PS, Chua CT, Teo SM, et al. Cadaveric renal transplantation at university hospital Kuala Lumpur: A Preliminary report. Transplant Proc 2000;32:1811-2. |
|19.||Courtney AE, Mcnamee PT, Maxwell AP. The evolution of renal transplantation in clinical practice: for better, for worse ? . Q J Med 2008;101:967-78. |
|20.||Mohamed AB, Mohamed AG. Living donor renal transplantation, 1976-2003: The Mansoura Experience. Saudi J Kidney Dis Transpl 2005;16:573-83. |
|21.||Tang H, Chelamcharla M, Baird BC, Shihab FS, Koford JK, Goldfarb-Rumyantzev AS. Factors affecting kidney-transplant outcome in recipients with lupus nephritis. Clin transplant 2008;22:263-72. |
|22.||Briganti EM, Wolfe R, Russ GR, Eris JM, Walker RG, McNeil JJ. Graft loss following renal transplantation in Australia: Is there a center effect?. Nephrol Dial Transplant 2002;17:1099-104. |
|23.||Feyssa E, Jones-Burton C, Ellison G, Philosophe B, Howell C. Racial/ethnic disparity in kidney transplantation outcomes: influence of donor and recipient characteristics. J Natl Med Assoc 2009;101:111-5. |
|24.||El-Husseini AA, Foda MA, Shokeir AA, Shehab El-Din AB, et al. Determinants of graft survival in pediatric and adolescent live donor kidney transplant recipients: A single center experience. Pediatr Transplant 2005;9:763-9. |
|25.||El-Husseini AA, Foda MA, Bakr MA, Shokeir AA, Sobh MA, Ghoneim MA. Pediatric live-donor kidney transplantation in Mansoura Urology& Nephrology Center: a 28-year perspective. Pediatr Nephrol 2006;21:1464-70. |
|26.||Park K, Kim YS, Kim MS, Kim SI, Oh CK, Han DS, et al. A 16-year experience with1275 primary living donor kidney transplants: univariate and multivariate analysis of risk factors affecting graft survival. Transplant Proc 1996;28:1578-9. |
|27.||Kaplan B, Schold JD, Meier-Kriesche HU. Long term graft survival with neoral and tacrolimus: a paired kidney analysis. J Am Soc Nephrol 2003;14:2980-4. |
|28.||Meier-Kriesche HU, Oje AO, Hason JA, Kaplan B. Hepatitis C antibody status and outcome in renal transplant recipients. Transplantation 2001;72:241-4. |
|29.||Shahbazian H, Hajiani E, Ehsanpour A. Patient and graft survival on allograft recipients with minimal hepatitis C virus infection: A case control study. Urol J 2008;5:178-83. |
|30.||Mitwalli AH, Alam A, Al-Wakeel J, Al Suwaida K, Tarif N, Schaar TA, et al. Effect of chronic viral hepatitis on graft survival in Saudi renal transplant patients. Nephron Clin Pract 2006;102:72-80. |
|31.||Kevin CM, Marshall MJ, Harold IF. Effect of the use or nonuse of long term dialysis on the subsequent survival of renal transplantation from living donor. N Engl J Med 2001;344:726-31. |
|32.||Rayhill SC, D'Alessandro AM, Odorico JS, Knechtle SJ, Pirsch JD, Heisey DM, et al. Simultaneous pancreas-kidney transplantation and living related donor renal transplantation in patients with diabetes: is there a difference in survival?. Ann Surg 2000;231:417-23. |
|33.||Sollinger HW. Mycophenolate mofetil for the prevention of acute rejection in primary renal allograft recipients. Transplantation 1995;60:225. |
|34.||Shapiro R, Jordan ML, Scantlebury VP, Vivas C, Marsh JW, McCauley J, et al. A prospective, randomized trial of tacrolimus/prednisone versus tacrolimus/prednisone/ mycophenolate mofetil in renal transplant recipients. Transplantation 1999;67:411-5. |
|35.||Ojo AO, Meier-Kriesche HU, Hanson JA, Leichtman AB, Cibrik D, Magee JC, et al. Mycophenolate mofetil reduces late renal allograft loss independent of acute rejection. Transplantation 2000;69:2405-9. |
|36.||Ciancio G, Miller J, Gonwa TA. Review of major clinical trials with mycophenolate mofetil in renal transplantation. Transplantation 2005;80:S191. |
|37.||Remuzzi G, Cravedi P, Costantini M, Lesti M, Ganeva M, Gherardi G, et al. Mycophenolate mofetil versus azathioprine for prevention of chronic allograft dysfunction in renal transplantation: The MYSS follow-up randomized, controlled clinical trial. J Am Soc Nephrol 2007;18:1973-85. |
|38.||Shapiro R, Jordan ML, Scantlebury VP, Vivas C, Gritsch HA, Fox-Hawranko L, et al. Reducing the length of stay after kidney transplantation - the intensive outpatient unit. Clin Transplant 1998;12:482-5. |
|39.||Orsenigo E, Socci C, Carlucci M, Zuber V, Fiorina P, Gavazzi F, et al. Multivariate analysis of factors affecting patient and graft survival after renal transplant. Transplant Proc 2005;37:2461-3. |
[Figure 1], [Figure 2], [Figure 3]
[Table 1], [Table 2]
|This article has been cited by|
||Survival of Renal Transplant Patients: Data From a Tertiary Care Center in Turkey
| ||H. Soylu,M. Oruc,O.K. Demirkol,E.S. Saygili,R. Ataman,M.R. Altiparmak,S. Pekmezci,N. Seyahi |
| ||Transplantation Proceedings. 2015; 47(2): 348 |
|[Pubmed] | [DOI]|
||Serum ß2-microglobulin at discharge predicts mortality and graft loss following kidney transplantation
| ||Brad C Astor,Brenda Muth,Dixon B Kaufman,John D Pirsch,R Michael Hofmann,Arjang Djamali |
| ||Kidney International. 2013; 84(4): 810 |
|[Pubmed] | [DOI]|
||Graft survival rate in pediatric renal transplantation: A single center experience
| ||Almasi-Hashiani, A. and Rajaeefard, A. and Hassanzade, J. and Salahi, H. and Mehrabani, D. and Khedmati, E. |
| ||Pakistan Journal of Medical Sciences. 2012; 28(5): 9 |
||Paid Donation: A Global View
| ||Ghahramani, N. and Rizvi, S.A.H. and Padilla, B. |
| ||Advances in Chronic Kidney Disease. 2012; 19(4): 262-268 |
||Creatinine-Based Equations Predicting Chronic Kidney Disease After Kidney Donation
| ||A.B. Libório,R.M. Barros,R.M. Esmeraldo,M.L.M.B. Oliveira,G.B. Silva,E.F. Daher |
| ||Transplantation Proceedings. 2011; 43(7): 2481 |
|[Pubmed] | [DOI]|
||Creatinine-based equations predicting chronic kidney disease after kidney donation
| ||Libório, A.B., Barros, R.M., Esmeraldo, R.M., Oliveira, M.L.M.B., Silva Jr., G.B., Daher, E.F. |
| ||Transplantation Proceedings. 2011; 43(7): 2481-2486 |
||Graft survival after living donor transplantation
| ||Mani, M.K. |
| ||Indian Journal of Nephrology. 2011; 21(2): 138 |
| ||Hassanzadeh, J., Hashiani, A.A., Rajaeefard, A., Salahi, H., Khedmati, E., Kakaei, F. |
| ||Indian Journal of Nephrology. 2011; 21(2): 138 |