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 ORIGINAL ARTICLE
Year : 2011  |  Volume : 21  |  Issue : 2  |  Page : 101-106

Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin


1 Laboratory of Pharmacology and Phytochemistry, Department of Cellular and Molecular Biology, Faculty of Sciences, University of Jijel, 18000, JiJel, Algeria
2 Laboratory of Molecular Toxicology, Department of Cellular and Molecular Biology, Faculty of Sciences, University of Jijel, 18000, JiJel, Algeria
3 Laboratory of Pharmacology and Phytochemistry, Department of Cellular and Molecular Biology, Faculty of Sciences, University of Jijel, 18000, JiJel; Laboratory of Molecular Toxicology, Department of Cellular and Molecular Biology, Faculty of Sciences, University of Jijel, 18000, JiJel, Algeria

Correspondence Address:
M Lahouel
Laboratory of Molecular Toxicology, Faculty of Sciences, University of Jijel, 18000, JIJEL
Algeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.82131

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We evaluated the effects of propolis extract on renal oxidative stress induced by doxorubicin throughout an analytical and pharmacological study of the eastern Algerian propolis using thin layer chromatography, ultra-violet-high-performance liquid chromatography) and gas chromatography-mass spectrometry. The pharmacological study was carried out in vivo on Wistar rat pre-treated with propolis extract 100 mg/kg/day for seven days. Doxorubicin at 10 mg/kg of body weight was administered intravenously on Day 7. Serum creatinine concentration, scavenging effect of flavonoids, lipid peroxidation and glutathione concentration were measured. Chemical analysis allowed identification and quantification of the phenolic compounds including pinostrombin chalcone (38.91%), galangin (18.95%), naringenin (14.27%), tectochrysin (25.09%), methoxychrysin (1.14%) and a prenylated coumarin compound suberosin (1.65%). The total flavonoid concentration in the propolis extract was 370 mg (quercetin equivalents QE) /g dry weight (QE/g DWPE). Propolis extract restored the renal functions and reduced the toxic effect of doxorubicin. These data show a protective effect of Algerian propolis extract against doxorubicin-induced oxidative stress.






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Indian Journal of Nephrology
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Online since 20th Sept '07