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 ORIGINAL ARTICLE
Year : 2011  |  Volume : 21  |  Issue : 2  |  Page : 90-94

Fetuin-A, inflammation, and coronary artery calcification in hemodialysis patients


1 Department of Nephrology, Selcuk University Meram School of Medicine, Konya, Turkey
2 Department of Nephrology, University Istanbul School of Medicine, Istanbul, Turkey
3 Department of Internal Medicine, University Istanbul School of Medicine, Istanbul, Turkey
4 Sisli Etfal Training Hospital, Istanbul, Turkey

Correspondence Address:
K Turkmen
Department of Nephrology, Selcuk University Meram School of Medicine, Konya
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.82128

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Hemodialysis patients have extremely increased cardiovascular mortality. Vascular calcification, inflammation, and low serum fetuin-A levels are implicated for increased mortality. In this study, relationship between coronary artery calcification, inflammation, and serum fetuin-A levels were investigated. Seventy-eight hemodialysis patients (38 male, 40 female, mean age: 52±14.5 years) were included. All patients were on dialysis for more than 6 months. Coronary artery calcium scores (CACS) are determined by electron-beam computed tomography. Serum CRP, IL-1β, IL-6, TNF-α, and serum fetuin-A levels were measured. Mean CACS value was 488.5±94.5. Serum fetuin-A levels were negatively correlated with CACS (r :−0.30, P=0.009). Patients are divided into two groups according to total CACS value; group 1 (CACS<10), group 2 (CACS≥10). There was a statistically significance difference in fetuin-A levels between CACS group 1 and group 2 (P=0.001). In this study, serum fetuin-A levels were associated with total CACS. This Fetuin-A may play a role in increased mortality in this group of patients via facilitating CAC.






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Indian Journal of Nephrology
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Online since 20th Sept '07