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 ORIGINAL ARTICLE
Year : 2012  |  Volume : 22  |  Issue : 4  |  Page : 280-284

Hyperuricemia beyond 1 year after kidney transplantation in pediatric patients: Prevalence and risk factors


Department of Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

Correspondence Address:
Z Rostami
Ground Floor of Baqiyatallah Hospital, Baqiyatallah Medical University, Mollasdra Ave., Vanak Squ., Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.101248

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Hyperuricemia is frequent among adult renal transplant recipients; however, data among pediatric kidney recipients are scarce. This study is designed to estimate the prevalence and risk factors of late post-transplant hyperuricemia in pediatric recipients. A retrospective observational multicenter study on 179 pediatric renal recipients (5-18 years) was conducted between April 2008 and January 2011 from five kidney transplant centers of Tehran, Iran. All recipients were followed up for more than 1 year (5.9 ±3.3 years) after transplantation. A total of 17686 blood samples were obtained for serum uric acid (SUA). The normal range of SUA was defined as SUA 1.86-5.93 mg/dl for children between 2 and 15 years in both genders; 2.40-5.70 mg/dl for girls aged >15 years; 3.40-7.0 mg/dl for boys aged >15 and more than 6 and 7 mg/dl in boys and girls older than 15 years old. The median age of the children was 13 years. Male recipients were more popular than female (male/female 59/41%). Hyperuricemia was detected in 50.2% of patients. Mean SUA concentration was 5.9±1.7 mg/dl and mean SUA concentration in hyperuricemic patients was 7.7±1.2 mg/dl. While at multivariate logistic regression elevated serum creatinine concentration (P>0.001) and the time span after renal transplantation (P=0.02) had impact on late post-transplant hyperuricemia. High cyclosporine level (C0 and C2) was not risk factor for huperuricemia. Late post-transplant hyperuricemia was found in about half of pediatric renal recipients, and was associated with impaired renal allograft function.






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Indian Journal of Nephrology
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Online since 20th Sept '07