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 ORIGINAL ARTICLE
Year : 2012  |  Volume : 22  |  Issue : 6  |  Page : 444-450

The expression of cytoskeletal proteins in kidney specimens of children with primary focal segmental glomerulosclerosis


1 Department of Pediatric Nephrology, Isfahan Kidney Diseases Research Center, Child Growth and Developement Research Center, Isfahan, Iran
2 Department of Pathology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3 Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Pediatric Nephrology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Social Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
A Gheissari
Department of Pediatric Nephrology, Associated Professor, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.106037

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Several studies have evaluated cytoskeletal proteins as prognostic factors for some types of nephrotic syndrome. However, studies concerning children with FSGS are scarce. This study was done to evaluate the glomerular, tubular, and interstitial expression of vimentin, desmin, and alpha smooth muscle actin (α-SMA) in kidney specimens of children with FSGS. Clinical and histologic data of 31 children with FSGS were reviewed. Thirty one formalin-fixed, paraffin-embedded kidney biopsy sections (3 μm) were selected for immunohistochemical staining. Double immunohistochemistry using a microwave-based two-color staining was applied. The mean age at onset in male and female was 56.3 ± 41.4 and 78.0 ± 60.4 months, respectively. The duration of follow-up was 46.3 ± 56.5 months. Interstitial fibrosis and tubular atrophy were reported in 42% and 54% of the patients, respectively. The latest evaluated mean blood pressure was significantly correlated with the expression of both vimentin and α-SMA in the interstitium (P < 0.05). However, we were not able to demonstrate any cytoskeletal protein expression as an independent predictor for renal survival. Further studies with larger sample size and longer follow-up periods are warranted to investigate the prognostic values of other histopathologic features in pediatrics with FSGS.






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Indian Journal of Nephrology
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Online since 20th Sept '07