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 ORIGINAL ARTICLE
Year : 2013  |  Volume : 23  |  Issue : 1  |  Page : 18-23

Association between high molecular weight apolipoprotein isoforms and lipoprotein levels in advanced chronic kidney disease and the effect of hemodialysis


1 Department of Biochemistry, University College of Medical Sciences (University of Delhi) & GTB Hospital, Dilshad Garden, Delhi, India
2 Department of Medicine, University College of Medical Sciences (University of Delhi) & GTB Hospital, Dilshad Garden, Delhi, India

Correspondence Address:
J K Gambhir
Department of Biochemistry, UCMS, Delhi
India
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Source of Support: Indian Council of Medical Research, New Delhi (52/10/98 BMS IRIS No 9801760),, Conflict of Interest: None


DOI: 10.4103/0971-4065.107189

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To explore the association between high molecular weight apo(a) isoforms and lipoprotein(a) [Lp(a)] in chronic kidney disease (CKD) and the effect of maintenance hemodialysis (MHD), plasma Lp(a) and apo(a) isoforms were determined in age and sex-matched CKD stage 4 and stage 5 patients (repeated after 4 weeks of MHD) and healthy controls ( n = 18). Median Lp(a) increased with severity of CKD. Upon HMW apo(a) isoform stratification, Lp(a) in S 2 isoform group was 37.6 mg/dl in CKD stage 4 and 64.0 mg/dl in stage 5 ( P < 0.024 and P < 0.001 vs. controls), whereas in S 3 + S 4 group there was no significant increase. Following MHD, Lp(a) also decreased significantly only in the S 2 group. Increase in Lp(a) in CKD patients with HMW apo(a) isoforms is mainly restricted to S 2 isoform group, furthermore, decrease in Lp(a) levels in response to MHD is also seen in this group only.






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Indian Journal of Nephrology
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Online since 20th Sept '07