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 CASE REPORT
Year : 2013  |  Volume : 23  |  Issue : 1  |  Page : 67-70

Sunitinib induced nephrotic syndrome and thrombotic microangiopathy


1 Department of Nephrology, Manipal Hospital, Bangalore, India
2 Department of Pathology, Manipal Hospital, Bangalore, India

Correspondence Address:
M Vankalakunti
Pathology and Laboratory Medicine, Manipal Hospital, #98, Rustom Bagh, HAL Airport Road, Bangalore - 560 017
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.107215

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Sunitinib is an oral, multitargeted receptor tyrosine kinase inhibitor of targets such as vascular endothelial growth factor and platelet derived growth factor receptor. It is used for the treatment of metastatic renal cell carcinoma (RCC). Use of sunitinib has been associated with renal dysfunction and nephrotic syndrome. However, simultaneous occurrence of nephrotic syndrome and renal dysfunction in a patient treated with sunitinib is rare. We report a case of metastatic RCC treated with sunitinib for 22 months who presented with nephrotic syndrome and renal dysfunction. Renal biopsy was diagnostic of thrombotic microangiopathy with diffuse effacement of podocytic foot process.






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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07