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  Table of Contents  
LETTER TO EDITOR
Year : 2014  |  Volume : 24  |  Issue : 3  |  Page : 197
 

Comment on: Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy


Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran

Date of Web Publication6-May-2014

Correspondence Address:
H Nasri
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.132026

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How to cite this article:
Nasri H. Comment on: Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy. Indian J Nephrol 2014;24:197

How to cite this URL:
Nasri H. Comment on: Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy. Indian J Nephrol [serial online] 2014 [cited 2020 Jul 14];24:197. Available from: http://www.indianjnephrol.org/text.asp?2014/24/3/197/132026


Sir,

I read with great interest the published article by Goswami et al., entitled "malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy (IgAN)". They presented a 39-year-old male who was admitted with sudden onset blurring of vision, generalized headache and vomiting. On examination, the patient had a blood pressure (BP) of 210/110 mm of Hg. Kidney biopsy was indicative of IgAN by significant mesangial IgA deposits and negative C1q deposits. According to Oxford classification, the morphologic lesions were as follow: M1, S1, E0 and T2. [1] In this article, I would like to emphasize a few points. Indeed, there was no reasonable etiology for malignant hypertension in this patient. There was no description of interstitial vessels, whereas various studies revealed the presence of thrombotic microangiopathy (TMA) in the background of IgAN, which is a factor for inappropriate high BP in IgAN. [2] Recently a retrospective study of 128 IgAN patients, from Paris revealed a 53% morphologic lesions of TMA, either acute or organized, in arteries and/or arterioles. [3] In a study on 136 kidney biopsies proved for IgAN, we found 2 patients had morphologic lesions of TMA and 10 patients had capillary tuft fibrinoid necrosis. [4],[5] In fact, few publications existed regarding the presence of TMA in IgAN. However, it seems to be uncommon in the setting of IgAN and its significance, as a concomitant histologic finding, is unclear. [2],[3] This morphologic lesion can be a reason for high BP in these patients. It is possible that IgAN has different presentation between different regions [2],[3] and while the vasculopathy in IgAN is ill-understood, therefore its role on the aggravation of IgAN needs further investigation.



 
  References Top

1.Goswami RP, Sinha D, Mondal S, Mandal S, Ete T, Nag A, et al. Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy. Indian J Nephrol 2013;23:390-2.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.Baradaran A. Renal vascular lesions in IgA nephropathy. J Ren Inj Prev 2013;2:37-8.  Back to cited text no. 2
    
3.Mubarak M. Oxford classification of IgA nephropathy: Broadening the scope of the classification. J Nephropathol 2012;1:13-6.  Back to cited text no. 3
    
4.El Karoui K, Hill GS, Karras A, Jacquot C, Moulonguet L, Kourilsky O, et al. A clinicopathologic study of thrombotic microangiopathy in IgA nephropathy. J Am Soc Nephrol 2012;23:137-48.  Back to cited text no. 4
    
5.Nasri H, Mubarak M. Significance of vasculopathy in IgA nephropathy patients with regard to Oxford classification and immunostaining findings: a single center experience. J Ren Inj Prev 2013;2:41-5.  Back to cited text no. 5
    




 

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