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Year : 2015  |  Volume : 25  |  Issue : 2  |  Page : 70-76

Hepatocyte nuclear factor-1β: A regulator of kidney development and cystogenesis


1 Department of Biochemistry, Panjab University, Chandigarh, India
2 Department of Nephrology, PGIMER, Chandigarh, India
3 Centre for Systems Biology and Bioinformatics, Under University Institute of Emerging Areas in Science and Technology, Panjab University, Chandigarh, India
4 Biotechnology Branch, University Institute of Engineering and Technology, Chandigarh; Centre for Stem Cell and Issue Engineering, University Institute of Emerging Areas in Science and Technology, Panjab University, Chandigarh, India

Correspondence Address:
Prof. S Puri
Biotechnology Branch, University Institute of Engineering and Technology and Center for Stem Cells and Tissue Engineering, Panjab University, Chandigarh - 160 014
India
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Source of Support: The work was supported by grant from Department of Biotechnology, (DBT), New Delhi. India to SP, Conflict of Interest: None


DOI: 10.4103/0971-4065.139492

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The understanding of the genomics of the renal tissue has gathered a considerable interest and is making rapid progress. The molecular mechanisms as well as the precise function of the associated molecular components toward renal pathophysiology have recently been realized. For the cystic kidney disease, the regulation of gene expression affecting epithelial cells proliferation, apoptosis as well as process of differentiation/de-differentiation represent key molecular targets. For the cystic disorders, molecular targets have been identified, which besides lending heterogeneity to cysts may also provide tools to unravel their functional importance to understand the renal tissue homeostasis. This review focuses on providing comprehensive information about the transcriptional regulatory role of hepatocyte nuclear factor-1β, a homeoprotein, as well as its interacting partners in renal tissue development and pathophysiology.






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Indian Journal of Nephrology
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Online since 20th Sept '07