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 ORIGINAL ARTICLE
Year : 2015  |  Volume : 25  |  Issue : 4  |  Page : 201-205

Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases


1 Department of Pathology, Manipal Hospital, Bengaluru, Karnataka, India
2 Department of Nephrology, Manipal Hospital, Bengaluru, Karnataka, India

Correspondence Address:
M Vankalakunti
Pathology and Laboratory Medicine, Manipal Hospital, #98, Rustom Bagh, HAL Airport Road, Bengaluru - 560 017, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.139093

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Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of "native" renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease.






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Indian Journal of Nephrology
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Online since 20th Sept '07