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 CASE REPORT
Year : 2016  |  Volume : 26  |  Issue : 2  |  Page : 142-144

Eosinophilic granulomatosis with polyangiitis with severe pulmonary hemorrhage treated with rituximab


1 Department of Nephrology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, India
2 Department of Nephropathology, Manipal Hospital, Bengaluru, Karnataka, India
3 Department of Radiology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, India
4 Department of Pulmonology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, India

Correspondence Address:
S Baikunje
Department of Nephrology, K. S. Hegde Medical Academy, Deralakatte, Mangalore, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.161021

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Eosinophilic granulomatosis with polyangiitis (EGPA) is characterized by systemic vasculitis, asthma and eosinophilia. Severe pulmonary hemorrhage is rare. Renal involvement is seen in approximately 25% and can vary from isolated urinary abnormality to rapidly progressive glomerulonephritis. There is limited evidence to support the use of rituximab in this condition. We present a patient with EGPA who had severe pulmonary hemorrhage and rapidly progressive glomerulonephritis. He responded to standard treatment including prednisolone, cyclophosphamide, and plasma exchange. He subsequently had a relapse of pulmonary hemorrhage that was treated successfully with rituximab.






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Indian Journal of Nephrology
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Online since 20th Sept '07