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 REVIEW
Year : 2016  |  Volume : 26  |  Issue : 2  |  Page : 86-96

Recent advances in anti-neutrophil cytoplasmic antibody-associated vasculitis


1 Department of Kidney Health Services, Royal Brisbane and Women's Hospital; School of Medicine, University of Queensland, Brisbane, Queensland, Australia
2 Department of Kidney Health Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia

Correspondence Address:
D Ranganathan
Department of Kidney Health Services, Royal Brisbane and Women's Hospital, Herston, Queensland - 4029
Australia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.171225

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Anti-neutrophil cytoplasmic antibody-associated vasculitis is an uncommon inflammatory disease of small to medium-sized vessels that frequently presents with rapidly progressive glomerulonephritis and renal failure though it can affect any organ system. If untreated, the vast majority of patients will die within a year. Current treatments improve prognosis but affected patients remain at a substantially higher risk of death and adverse outcomes. We review the classification of the disease, our understanding of the pathogenesis and epidemiology, and propose future directions for research. We also evaluate the evidence supporting established treatment regimens and the progress of clinical trials for newer treatments to inform the design of future studies.






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Indian Journal of Nephrology
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Online since 20th Sept '07