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 CASE REPORT
Year : 2018  |  Volume : 28  |  Issue : 5  |  Page : 385-388

Adenovirus interstitial nephritis: An unusual cause for early graft dysfunction


1 Department of Nephrology, G. Kuppuswamy Naidu Memorial Hospital, Coimbatore, Tamil Nadu, India
2 Center for Renal and Urological Pathology Private Limited, Chennai, Tamil Nadu, India

Correspondence Address:
A A Kurien
Center for Renal and Urological Pathology Private Limited, Chennai - 600 040, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijn.IJN_218_16

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We describe a rare case of adenovirus interstitial nephritis in a 37-year-old man, 4 weeks following deceased donor renal transplantation. He presented with gross hematuria and acute graft dysfunction. A renal biopsy revealed necrotizing tubulointerstitial nephritis with intranuclear viral inclusions in the tubular epithelial cells. Immunohistochemistry and polymerase chain reaction confirmed adenovirus infection. Reduction in immunosuppression alone resulted in rapid improvement of graft function. Awareness of the clinical and characteristic biopsy findings may help establish the correct diagnosis, which is crucial as disseminated infection, if left untreated, is associated with a high mortality rate in renal allograft recipients.






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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07