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Year : 2019  |  Volume : 29  |  Issue : 2  |  Page : 122-124

Cytomegalovirus induced collapsing glomerulopathy and necrotizing glomerulonephritis in a renal allograft recipient

1 Department of Pathology, Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India
2 Department of Nephrology, Stanley Medical College, Royapuram, Chennai, Tamil Nadu, India

Correspondence Address:
A A Kurien
Renopath, Center for Renal and Urological Pathology, No. 27 and 28, VMT Nagar, Kolathur, Chennai - 600 099, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_375_17

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In renal allograft recipients, cytomegalovirus (CMV) typically causes tubulointerstitial nephritis. Only rarely glomeruli are involved. We present a rare case of CMV with collapsing glomerulopathy, necrotizing glomerulonephritis, and crescent formation in a renal allograft recipient. Immunohistochemistry confirmed CMV infection. The patient was started on valganciclovir and his renal function remained stable. A repeat renal biopsy performed three months later showed morphologically normal glomeruli and CMV immunostaining was also negative. Nephropathologists have to carefully screen for CMV in cases with crescentic or collapsing glomerulopathy as the later lesions resolve after treating the underlying viral infection. This study will add on to the various glomerular changes associated with CMV infection.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07