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Official publication of the Indian Society of Nephrology
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Hyponatremia - A rare complication of Gitelman's syndrome

 Division of Nephrology, Georgetown University/Washington Hospital Center, Washington, DC 20010, USA, India

Correspondence Address:
A Ganguli,
Georgetown University/Washington Hospital Center, 110 Irving Street, NW, Suite 2A70, Washington, DC 20010
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Source of Support: None, Conflict of Interest: None

Gitelman's syndrome (GS) is a rare autosomal recessive disorder caused by mutations in thiazide-sensitive NaCl cotransporter. We report a 49-year-old, normotensive lady with prolonged hypokalemia since her 20s who was diagnosed with GS at our renal clinic. During follow-up, she was found to have mild, asymptomatic, euvolemic hyponatremia with low serum uric acid, inappropriately high urine osmolality and sodium consistent with syndrome of inappropriate antidiuretic hormone-like presentation. Despite life-long urinary sodium losses, hyponatremia has rarely been reported in GS to be due to the primary disease process. We present relevant clinical data and hypothesize on why this disease per se may be a risk factor for dilutional hyponatremia.

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    -  Veis J H
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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07