Indian Journal of Nephrology About us |  Subscription |  e-Alerts  | Feedback | Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Current Issue | Archives| Ahead of print | Search |Instructions |  Editorial Board  

Users Online:221

Official publication of the Indian Society of Nephrology
 
CASE REPORT
Ahead of Print

Successful treatment of multiple angiomyolipomas with sirolimus in a child


1 Department of Paediatrics, Children's Hospital at the London Health Sciences Centre, London, Ontario, Canada
2 Department of Paediatrics, Children's Hospital at the London Health Sciences Centre; Department of Pathology and Laboratory Medicine; Department of Medicine, University of Western Ontario, London, Ontario, Canada

Correspondence Address:
G Filler,
Department of Paediatrics, Children's Hospital of Western Ontario, 800 Commissioners Road East, London, Ontario, N6A 5W9
Canada
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Tuberous sclerosis complex frequently results in the formation of renal angiomyolipomas (AMLs). Sirolimus (SIR) or everolimus can be used to treat large AMLs, although this treatment has rarely been described in children, particularly for multiple renal AMLs. A 15-year-old girl presented with bilateral severe chronic flank pain coinciding with increased renal size and hundreds of renal AMLs. We opted to treat her with SIR over the course of 3.5 years. Following her treatment, her renal size had substantially decreased and the AMLs had shrunk. The patient's pain subsided as well. Our case, which has never been described in published literature, demonstrates that a child with multiple renal AMLs can be treated with SIR, and suggests that this treatment may be a viable option for preventing the development of secondary morbidities such as chronic pain.


Print this article
Search
 Back
 
  Search Pubmed for
 
    -  Pabedinskas K
    -  Kobrzynski M
    -  Filler G
 Citation Manager
 Article Access Statistics
 Reader Comments
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed94    
    PDF Downloaded7    

Recommend this journal

Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07