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CASE REPORT
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Methylene blue induced methemoglobinemia with acute kidney injury in a glucose-6-phosphate dehydrogenase-deficient Patient


1 Department of Nephrology, Super Speciality Hospital and Government Medical College, Nagpur, Maharashtra, India
2 Department of Medicine, Northern Railway Central Hospital, New Delhi, India

Correspondence Address:
MR Balwani,
Department of Nephrology, Super Speciality Hospital and Government Medical College, Nagpur - 440 003, Maharashtra
India
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Source of Support: None, Conflict of Interest: None

Our case was treated with methylene blue for symptomatic nitrobenzene poisoning. After which he developed methemoglobinemia with acute kidney injury due to hemolysis and on further testing, he was found to be glucose-6-phosphate dehydrogenase(G6PD) enzyme deficient. Thus, afterward, the patient was treated with only available mode of treatment as repeated blood transfusions and ascorbic acid with dialysis support to which the patient responded. Thus, it is important to evaluate for the G6PD deficiency where methylene blue treatment is planned as an antidote to nitrobenzene compounds poisoning.


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Indian Journal of Nephrology
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Online since 20th Sept '07