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Official publication of the Indian Society of Nephrology
 
CASE REPORT
Ahead of Print

Type I cryoglobulinemic nephritis in a patient of monoclonal gammopathy of renal significance


1 Department of Nephrology, King Edward Memorial Hospital, Pune, Maharashtra, India
2 Department of Hematology, King Edward Memorial Hospital, Pune, Maharashtra, India
3 Department of Pathology, King Edward Memorial Hospital, Pune, Maharashtra, India

Correspondence Address:
VA Lobo,
Department of Nephrology, King Edward Memorial Hospital, 489, Rasta Peth, Sardar Moodliar Road, Pune - 411 011, Maharashtra
India
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Source of Support: None, Conflict of Interest: None

Monoclonal gammopathy of renal significance is a recently described entity in which a small B-cell clone not meeting the criteria for the diagnosis of multiple myeloma produces renal disease usually through deposition of a secreted monoclonal immunoglobulin. Here, we describe a case of Type I cryoglobulinemic glomerulonephritis diagnosed on a kidney biopsy and caused by a monoclonal IgM produced by a small bone marrow clone. The patient made a complete renal recovery after chemotherapy to suppress the clone.


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    -  Lobo V A
    -  Subramaniam K
    -  Bidaye M A
    -  Deshpande S
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Indian Journal of Nephrology
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Online since 20th Sept '07