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Official publication of the Indian Society of Nephrology
 
CASE REPORT
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Dense deposit disease involving C3 and C4d deposits


1 Department of Nephropathology, Manipal Hospital, Bengaluru, Karnataka, India
2 Department of Nephrology, Manipal Hospital, Bengaluru, Karnataka, India

Correspondence Address:
M Vankalakunti,
Department of Nephropathology, Manipal Hospital, Rustom Bagh, Bengaluru - 560 017, Karnataka
India
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Source of Support: None, Conflict of Interest: None

Dense deposit disease (DDD), earlier called Type II membranoproliferative glomerulonephritis is distinct disease having frequent relapses reaching end-stage kidney disease by 10-year in up to 50%–60% of cases and high recurrence rate in the allograft. The term DDD is derived from its distinctive ribbon-like osmiophilic deposits in the lamina densa of glomerular basement membrane by electron microscopy. Pathogenetically, alternate pathway dysfunction leads to this disease, which is diagnosed by ultrastructure. Herein, we describe our observation of C4d positivity in an adolescent boy with DDD.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07