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Official publication of the Indian Society of Nephrology
 
REVIEW ARTICLE
Ahead of Print

Therapeutic plasma exchange in renal disorders


1 Department of Renal Medicine, Metro North Hospital and Health Services, Herston; School of Medicine, Griffith University, Australia, Nathan, Australia
2 Department of Renal Medicine, Metro North Hospital and Health Services, Herston, Australia; MGR Medical University, Chennai, Tamil Nadu, India

Correspondence Address:
D Ranganathan,
Level 9, Ned Hanlon Building, Butterfield Street, Royal Brisbane and Women's Hospital, Herston QLD
Australia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_420_17

Nephrologists use hemodialysis and hemofiltration to remove low molecular weight toxic constituents, and increasingly deploy therapeutic plasma exchange (TPE)/plasmapheresis to eliminate higher molecular weight substances such as immunoglobulins or immune complexes from plasma. This review discusses different modalities of TPE, their application in renal disorders, its rationale and complications. TPE is recommended based on evidence, in alloantibody-mediated diseases such as humoral antibody mediated renal transplant rejection, autoantibody mediated glomerulonephritis (GN) disorders for example, anti-glomerular basement membrane GN, as well as in antineutrophil cytoplasmic antibody mediated GN and antibody mediated thrombotic thrombocytopenic purpura. In many other renal illnesses, the rational use of TPE is gaining currency. Double membrane filtration, immune adsorption and cryofiltration are important modifications in TPE


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Indian Journal of Nephrology
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Online since 20th Sept '07