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Official publication of the Indian Society of Nephrology
 
CASE REPORT
Ahead of Print

Acute interstitial nephritis in a patient with high aluminum blood levels: A case report


1 Department of Nephrology, Yashoda Hospitals, Alexander Road, Secunderabad, Telangana, India
2 Department of Neurology, Yashoda Hospitals, Alexander Road, Secunderabad, Telangana, India

Correspondence Address:
Urmila Anandh,
Department of Nephrology, Yashoda Hospitals, Alexander Road, Secunderabad - 500 003, Telangana
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_320_18

A known case of hypertension and recent onset diabetes presented to our neurological clinic with symptoms of ataxia, rigidity, and tremors. His symptoms were of relatively recent onset. He gave no history of any renal disease in past. The magnetic resonance imaging of the brain done by the neurologist was suggestive of demyelinating pathology. His renal functions showed progressive deterioration (Cr 1.4 mg/dl about 3 months back to 2.2 mg/dl at present) along with the onset of his neurological illness. An extensive work up for autoimmune encephalitis and paraneoplastic syndrome was noncontributory. A toxicology screen revealed high levels of aluminum in the blood. A renal biopsy showed features of interstitial nephritis and predominant vacuolar injury of the proximal tubule (suggestive of toxic injury.) On further questioning, the patient gave history of using an over the counter native medication. The medication was stopped and weekly desferrioxime chelation advised. A short course of steroids (0.5 mg/kg/day tapering dose for 6 weeks) was also given. The creatinine stabilized to 1.3 mg/dl on follow-up after 3 months. The neurological symptoms also resolved completely.


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    -  Anandh U
    -  Kumar Ch. R
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Indian Journal of Nephrology
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Online since 20th Sept '07