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Official publication of the Indian Society of Nephrology
 
CASE REPORT
Ahead of Print

Rare, yet emerging cause of graft dysfunction—ALECT 2 amyloidosis


1 Division of Nephrology, Grecian Hospital, Mohali, Punjab, India
2 Department of Histopathology, Core Diagnostics, Gurgaon, Haryana, India
3 Department of Histopathology, Medicos Centre, Chandigarh, India
4 Department of Transplant Surgery, Surya Kidney Hospital, Mohali, Punjab, India

Correspondence Address:
Kulwant Singh,
Division of Nephrology, Grecian Hospital, Sector 69, Mohali - 160 062, Punjab
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_258_19

Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. Amyloidosis derived from leukocyte cell-derived chemotaxin 2 (LECT2) is a recently recognized form of amyloidosis in the United States with predominant involvement of kidney and liver. We present a case of ALECT2 renal amyloid in a transplant recipient who presented with gradual worsening of graft function and subnephrotic proteinuria. To our knowledge, this is first case of LECT2 amyloidosis from Northern India in a transplant recipient. There is no effective therapy for amyloidosis derived from leukocyte cell-derived chemotaxin 2.


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Indian Journal of Nephrology
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