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Official publication of the Indian Society of Nephrology
 
CASE REPORT
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Bilateral acute renal infarction secondary to methylene tetrahydrofolate reductase A1298C and PAI-1 mutation


 Department of Nephrology, Institute of Renal Science, Sir Gangaram Hospital, New Delhi, India

Correspondence Address:
Priti Meena,
Institute of Renal science, Sir Gangaram Hospital, New Delhi
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_65_20

We present this rare case of hyperhomocysteinemia due to a mutation in methylene-tetrahydrofolate-reductase (MTFHR) combined with plasminogen activator inhibitor deficiency, causing bilateral renal artery thrombosis. This case highlights the importance of genetic screening in individuals with a family history of thrombotic diseases. There seems to be a role of intervention, even in the setting of renal infarction.


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    -  Bhalla AK
    -  Bhargava V
    -  Meena P
    -  Bhoiyar A
    -  Yadav A
    -  Rana DS
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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07