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Naproxen induced acute interstitial nephritis with renal cortical necrosis

1 Department of Nephrology, Aster Medcity Hospital, Kochii, Kerala, India
2 Department of Pathology, Aster Medcity Hospital, Kochii, Kerala, India

Correspondence Address:
V Narayanan Unni,
Lead Senior Consultant, Nephrology, Aster Medcity Hospital, Kuttisahib Road, Near Kothad Bridge, South Chittor P. O, Cheranelloor, Kochi - 682 027, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_75_19

Drug induced acute interstitial nephritis is an idiosyncratic reaction following a drug exposure. The commonest drugs implicated are nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics and proton pump inhibitors. Renal cortical necrosis is a rare cause of acute kidney injury caused by severe and sustained vasoconstriction of small renal vessels. There is a change in the epidemiology of acute kidney injury especially in developing countries where drug induced acute kidney injury is becoming increasingly common. Naproxen is known to cause renal failure by renal papillary necrosis, tubular damage and acute interstitial nephritis. We present a case of Naproxen induced acute interstitial nephritis with acute cortical necrosis. To the best of our knowledge this is the first documented case of Naproxen induced renal cortical necrosis.

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