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Year : 2007  |  Volume : 17  |  Issue : 2  |  Page : 73--75

Propylthiouracil-associated antineutrophil cytoplasmic antibody positive crescentic glomerulonephritis

R Bonu, V Siddini, K Babu, S Ballal 
 Manipal Institute of Nephrology and Urology, Manipal Hospital, Bangalore, Karnataka, India

Correspondence Address:
S Ballal
Manipal Institute of Nephrology and Urology, Manipal Hospital, # 98, Rustom Bagh, Airport Road, Bangalore - 560 017, Karnataka
India

The vasculitic syndromes of Wegeners granulomatosis, microscopic polyangitis, Churg-Strauss syndrome and renal limited variants are associated with antineutrophil cytoplasmic antibodies (ANCA). Positive ANCA are also seen in many viral infections, inflammatory bowel diseases and drugs. Drug-induced ANCA-associated renal disease is reported less frequently than drug-induced lupus nephritis. ANCA-positive crescentic glomerulonephritis due to propylthiouracil has been reported in children and adults especially in Japanese population. The renal outcome is better in propylthiouracil-associated ANCA-positive crescentic GN as compared with nondrug-induced crescentic GN. Propylthiouracil-associated ANCA-positive crescentic GN may or may not require steroid and cytotoxic therapy depending on the severity of renal failure. We report a case of propylthiouracil-associated ANCA-positive crescentic GN with severe renal failure; the renal function improved after steroid and cytotoxic therapy.

How to cite this article:
Bonu R, Siddini V, Babu K, Ballal S. Propylthiouracil-associated antineutrophil cytoplasmic antibody positive crescentic glomerulonephritis.Indian J Nephrol 2007;17:73-75

How to cite this URL:
Bonu R, Siddini V, Babu K, Ballal S. Propylthiouracil-associated antineutrophil cytoplasmic antibody positive crescentic glomerulonephritis. Indian J Nephrol [serial online] 2007 [cited 2019 Dec 10 ];17:73-75
Available from: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2007;volume=17;issue=2;spage=73;epage=75;aulast=Bonu;type=0