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Year : 2010  |  Volume : 20  |  Issue : 1  |  Page : 9--14

Paraoxonase: Its antiatherogenic role in chronic renal failure

M Prakash, NM Phani, R Kavya, M Supriya 
 Department of Biochemistry, Kasturba Medical College, Manipal - 576 104, India

Correspondence Address:
M Prakash
Department of Biochemistry, Kasturba Medical College, Manipal - 576 104
India

Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. The PON family has three members (PON1, PON2 and PON3); they share structural properties and enzymatic activities. PON1 is shown to reside over high density lipoprotein (HDL) and has both antioxidant and antiatherogenic functions. Function of PON2 and PON3 are speculative and still under research. Several methodologies were developed over the years to determine the activity and mass of PON1, of which spectrophotometer-based methods using certain chemicals as substrate predominate. Several studies have shown decreased levels of PON1 in chronic renal failure (CRF) patients, particularly those on hemodialysis. The role of PON1 in development of cardiovascular disease has drawn considerable attention in recent years. Several authors have shown decreased levels of HDL and PON1 activity in CRF patients on hemodialysis and reported this to be a risk factor in the development of CVD. Enhancement or maintenance of the PON1 activity may prevent development of CVDs and its consequences in patients on hemodialysis.

How to cite this article:
Prakash M, Phani N M, Kavya R, Supriya M. Paraoxonase: Its antiatherogenic role in chronic renal failure.Indian J Nephrol 2010;20:9-14

How to cite this URL:
Prakash M, Phani N M, Kavya R, Supriya M. Paraoxonase: Its antiatherogenic role in chronic renal failure. Indian J Nephrol [serial online] 2010 [cited 2020 Aug 4 ];20:9-14
Available from: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2010;volume=20;issue=1;spage=9;epage=14;aulast=Prakash;type=0