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Year : 2019  |  Volume : 29  |  Issue : 1  |  Page : 8--14

Time of cold ischemia and delayed graft function in a cohort of renal transplant patients in a reference center

JF Nieto-Rios1, CL Ochoa-García2, A Serna-Campuzano3, B Benavides-Hermosa2, LL Calderón-Puentes2, A Aristizabal-Alzate2, C Ocampo-Kohn1, G Zuluaga-Valencia2, LM Serna-Higuita4 
1 Department of Nephrology Kidney Transplant, Hospital Pablo Tobón Uribe; Department of Internal Medicine, University of Antioquia, Medellin, Colombia
2 Department of Nephrology Kidney Transplant, Hospital Pablo Tobón Uribe, Medellin, Colombia
3 Deparment of Internal Medicine, Faculty of Medicine, Universidad Pontificia Bolivariana, Medellin, Colombia
4 Faculty of Medicine, Institute for Clinical Epidemiology and Applied Biometrics, Eberhard Karls University, Tuebingen, Germany

Correspondence Address:
L M Serna-Higuita
Institute for Clinical Epidemiology and Applied Biometrics, University Hospital Tubingen, Silcherstrase 5, Floor 7, Office Number: 301, Postal Code: 72076, Tuebingen
Germany

There are many factors involved in the delayed graft function of a renal graft, with prolonged cold ischemia time being one of the most relevant. The aim of this study is to evaluate the relationship between the time of cold ischemia and the delayed graft function, and acute rejection and graft loss at 1 year of follow-up. A retrospective cohort of 347 renal transplant patients were evaluated during the years 2009–2013. The incidence of delayed graft function was 18.4% (n = 65). The cold ischemia time was an independent risk factor for delayed graft function (odds ratio [OR] 1.10, 95% confidence interval [CI] 1.04–1.16). By grouping the time of cold ischemia by intervals, the risk of delayed graft function was greater in the 12–18 hours group (OR 2.06, 95% CI 1.02–4.15) and in the >18 hours group (OR 3.38, 95% CI 1.57–7.27). The risk of acute rejection did not increase with longer cold ischemia (p = 0.69), and cold ischemia time was not a risk factor for renal graft loss at 1-year follow-up (hazard ratio 0.97, 95% CI 0.88–1.06). In conclusion the time of cold ischemia (>12 hours) in renal transplant recipients of optimal deceased donors increases the risk of delayed graft function; however, this does not negatively impact the results in acute rejection or graft loss in the first year of the transplant.

How to cite this article:
Nieto-Rios J F, Ochoa-García C L, Serna-Campuzano A, Benavides-Hermosa B, Calderón-Puentes L L, Aristizabal-Alzate A, Ocampo-Kohn C, Zuluaga-Valencia G, Serna-Higuita L M. Time of cold ischemia and delayed graft function in a cohort of renal transplant patients in a reference center.Indian J Nephrol 2019;29:8-14

How to cite this URL:
Nieto-Rios J F, Ochoa-García C L, Serna-Campuzano A, Benavides-Hermosa B, Calderón-Puentes L L, Aristizabal-Alzate A, Ocampo-Kohn C, Zuluaga-Valencia G, Serna-Higuita L M. Time of cold ischemia and delayed graft function in a cohort of renal transplant patients in a reference center. Indian J Nephrol [serial online] 2019 [cited 2019 Jul 22 ];29:8-14
Available from: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2019;volume=29;issue=1;spage=8;epage=14;aulast=Nieto-Rios;type=0