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Year : 2020  |  Volume : 30  |  Issue : 1  |  Page : 47--49

Membranous nephropathy with rapid progression

R Vairakkani, K Thirumal Valavan, M Edwin Fernando, T Yashwanth Raj 
 Department of Nephrology, Government Stanley Medical College and Hospital, Old Jail Road, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. K Thirumal Valavan
Department of Nephrology, Government Stanley Medical College and Hospital, Old Jail Road, Chennai - 600 001, Tamil Nadu
India

We report a 49-year-old man with microscopic hematuria, subnephrotic proteinuria, and rapidly progressive renal failure. His biopsy had features of PhosphoLipase A2 Receptor (PLA2R) positive membranous nephropathy with circumferential cellular crescents. Further work-up revealed IgG antiGlomerular Basement Membrane (anti-GBM) antibody titer of 188 U/mL (normal <7 U/mL). A final diagnosis of membranous nephropathy with anti-GBM disease was made. These two distinct pathological entities can occur together resulting in significant morbidity and mortality unless diagnosed early and treatment initiated promptly. Outcomes have been poor, given the nonspecific presentation and delay in diagnosis.

How to cite this article:
Vairakkani R, Valavan K T, Fernando M E, Raj T Y. Membranous nephropathy with rapid progression.Indian J Nephrol 2020;30:47-49

How to cite this URL:
Vairakkani R, Valavan K T, Fernando M E, Raj T Y. Membranous nephropathy with rapid progression. Indian J Nephrol [serial online] 2020 [cited 2020 Jul 14 ];30:47-49
Available from: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2020;volume=30;issue=1;spage=47;epage=49;aulast=Vairakkani;type=0