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Year : 2020  |  Volume : 30  |  Issue : 2  |  Page : 72--76

Vitamin D receptor activity, vitamin D status, and development of de-novo donor-specific antibody after renal transplantation

Sonia Mehrotra, Raj K Sharma, Mahabaleshwar Mayya 
 Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Rae Bareli Road, Lucknow, Uttar Pradesh, India

Correspondence Address:
Raj K Sharma
Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow - 226 014, Uttar Pradesh
India

Introduction: Vitamin D has immunomodulatory properties and could have a role in allograft outcome. Methods: Fifty-two chronic kidney disease patients going for transplantation were studied for vitamin-D receptor (VDR) activity, 25(OH)D, estimated glomerular filtration rate (e-GFR), and de-novo donor-specific antibody (d-DSA). Results: Vitamin D deficiency was seen in 25% of recipients before transplant (26.09 ± 12.19 ng/ml), in 48.1% at 6 months posttransplant (23.36 ± 15.11 ng/ml). VDR activity before the transplant was 15.41 ± 31.41 ng/ml, which was similar to control group (13.24 ± 9.78 ng/ml), and after transplantation showed an increase at 3 months to 21.91 ± 38.80 ng/ml and at 6 months to 26.03 ± 53.90 ng/ml. d-DSA developed in 27.3% and 6.7% patients of vitamin D-deficient patients (levels <31 ng/ml) and non-deficient (levels ≥20 ng/ml) patients respectively (P < 0.042). Low VDR activity at 3 months posttransplant was associated with significantly higher d-DSA positivity (33.3%) as compared to the group with normal VDR activity where d-DSA developed only in 5.9% of patients (P < 0.009). Patients with vitamin D levels <20 ng/ml and the group with low VDR activity at 3 months had significantly less e-GFR at 1 year after transplant. Conclusion: d-DSA was associated with vitamin D deficiency and low VDR activity with decreased graft GFR at 12 months posttransplant.

How to cite this article:
Mehrotra S, Sharma RK, Mayya M. Vitamin D receptor activity, vitamin D status, and development of de-novo donor-specific antibody after renal transplantation.Indian J Nephrol 2020;30:72-76

How to cite this URL:
Mehrotra S, Sharma RK, Mayya M. Vitamin D receptor activity, vitamin D status, and development of de-novo donor-specific antibody after renal transplantation. Indian J Nephrol [serial online] 2020 [cited 2020 Jul 11 ];30:72-76
Available from: http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2020;volume=30;issue=2;spage=72;epage=76;aulast=Mehrotra;type=0