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 CASE REPORT
Year : 2012  |  Volume : 22  |  Issue : 1  |  Page : 59-61

Treatment of gabapentin-induced myoclonus with continuous renal replacement therapy


1 Department of Internal Medicine, Harlem Hospital Center, New York, USA
2 Division of Nephrology, Harlem Hospital Center, New York, USA
3 Department of Medicine, Division of Nephrology, Columbia University, New York, USA

Correspondence Address:
A K Guddati
Department of Internal Medicine, Harlem Hospital Center, 506, Lenox Avenue, New York, NY - 10036
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.83744

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A 56-year-old man with diabetes, hypertension, and chronic kidney disease presented to the emergency room with a complaint of pain in his right foot. He was found to have tremors. Gabapentin toxicity was suspected and the patient was found to have high gabapentin level (6.3 mcg/ml). Patient was commenced on continuous venovenous hemodiafiltration (CVVHD) and the pharmacokinetics of gabapentin was studied. The patient improved symptomatically and his tremors subsided. In this case report, we describe the successful management of gabapentin toxicity with continuous renal replacement therapy and calculate the clearance of gabapentin which will enable future treatment of gabapentin toxicity by CVVHD.






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Indian Journal of Nephrology
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Online since 20th Sept '07