Nondiabetic kidney disease in type 2 diabetic patients: A single center experience

U Das; KV Dakshinamurty; A Prayaga; MS Uppin

doi:10.4103/0971-4065.103912

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ORIGINAL ARTICLE

Year : 2012 | Volume : 22 | Issue : 5 | Page : 358-362

Nondiabetic kidney disease in type 2 diabetic patients: A single center experience

U Das¹, KV Dakshinamurty¹, A Prayaga², MS Uppin²
¹ Department of Nephrology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India
² Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, India

Correspondence Address:
U Das
Department of Nephrology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad - 500 082, Andhra Pradesh
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0971-4065.103912

Nondiabetic renal disease (NDRD) is seen as a cause of proteinuria and renal failure in type 2 diabetes mellitus (DM). The clinical differences between NDRD and diabetic glomerulosclerosis (DGS) are not clear. This study was done to find the spectrum of NDRD in type 2 DM patients and differences in clinical profile between NDRD and DGS patients. Data of patients with type 2 DM who underwent renal biopsy in this institute from 1990 to 2008 were analyzed retrospectively. Patients were categorized as isolated NDRD, NDRD with DGS, and isolated DGS. A total of 75 patients were included. Mean age was 45 ± 10.2 years, male to female ratio was 3.1 : 1, median duration of DM was 12 months (range, 1 year-15 years), proteinuria was 4.2 ± 3.4 g/day, and serum creatinine was 4.3 ± 3.9 mg/dl. Hypertension was observed in 63 (84%) cases and microscopic hematuria in 24 (32%) cases. Nephrotic syndrome (38.7%) was the commonest clinical presentation. Forty-eight (64%) cases had NDRD and 27 (36%) had DGS. The commonest NDRD was minimal change disease (12.5%). Three (6.3%) patients had lupus nephritis. Tubulointerstitial nephritis has been observed in 10.4% patients. No significant differences between NDRD and DGS patients were found except hypertension which was significantly high in the DGS group. Acute kidney injury and nephritic syndrome were not observed in the DGS group. In conclusion, the incidence of biopsy-proven NDRD in type 2 DM in this study was high. Kidney biopsy aided in the detection of NDRD in clinically suspected patients.

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