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Year : 2013  |  Volume : 23  |  Issue : 1  |  Page : 54-56

Encephalopathy secondary to isoniazid in patients on hemodialysis

1 Department of Medicine, Hamad General Hospital, Doha, Qatar
2 Medical Department, AlWakra Health Center, Doha, Qatar

Correspondence Address:
M T Abbas
Department of Medicine, Hamad General Hospital, P O Box 3050, Doha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.107206

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We report isoniazid (INH)-induced encephalopathy in two male patients on hemodialysis. One of them had tuberculous adenitis, and the other had pulmonary tuberculosis. Both were given rifampicin, INH, pyrazinamide, and ethambutol with pyridoxine 40 mg/day. Two patients developed disturbances in consciousness. After excluding other causes, INH-induced encephalopathy was suspected so the drug was stopped and dose of pyridoxine increased. Both patients retained their consciousness within 1 week and were discharged.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07