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 ORIGINAL ARTICLE
Year : 2013  |  Volume : 23  |  Issue : 3  |  Page : 201-205

Prevalence and risk factors of hyperuricemia among kidney transplant recipients


1 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, I.R. Iran
2 Department of Nephrology, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran

Correspondence Address:
Z Rostami
Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran
I.R. Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.111849

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Hyperuricemia is common in renal transplant patients (RTRs), especially those on cyclosporine (CsA)-based therapy. We conducted a retrospective study to determine the prevalence of hyperuricemia and its risk factors among RTRs. A total of 17,686 blood samples were obtained from 4,217 RTRs between April 2008 and January 2011. Hyperuricemia was defined as an uric acid level of ≥7.0 mg/dl in men and of ≥6 mg/dl in women that persisted for at least two consecutive tests. Majority (68.2%) of RTRs were normouricemic. Hyperuricemia was more frequent in younger and female RTRs. On multivariate logistic regression, we found high trough level of cyclosporine to be a risk factor for hyperuricemia. In addition, female gender, impaired renal function, and dyslipidemia (hypercholesterolemia, hypertriglyceridemia, and elevated LDL) were also associated with higher probability of hyperuricemia. Hyperuricemia is a common complication after renal transplantation. Risk factors implicated in post-transplant hyperuricemia include high trough level of cyclosporine, female gender, renal allograft dysfunction, and dyslipidemia.






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Indian Journal of Nephrology
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Online since 20th Sept '07