Indian Journal of Nephrology About us |  Subscription |  e-Alerts  | Feedback | Login   
  Print this page Email this page   Small font sizeDefault font sizeIncrease font size
 Home | Current Issue | Archives| Ahead of print | Search |Instructions |  Editorial Board  

Users Online:1244

Official publication of the Indian Society of Nephrology
 ~  Similar in PUBMED
 ~  Search Pubmed for
 ~  Search in Google Scholar for
 ~Related articles
 ~  Article in PDF (568 KB)
 ~  Citation Manager
 ~  Access Statistics
 ~  Reader Comments
 ~  Email Alert *
 ~  Add to My List *
* Registration required (free)  

   Materials and Me...
   Article Figures
   Article Tables

 Article Access Statistics
    PDF Downloaded178    
    Comments [Add]    
    Cited by others 2    

Recommend this journal


  Table of Contents  
Year : 2013  |  Volume : 23  |  Issue : 4  |  Page : 264-269

Melatonin improves sleep quality in hemodialysis patients

1 Department of Internal Medicine; Division of Nephrology, Sardasht, Arak Medical Sciences University, Arak, Iran
2 Department of Internal Medicine, Sardasht, Arak Medical Sciences University, Arak, Iran

Date of Web Publication4-Jul-2013

Correspondence Address:
M Edalat-Nejad
Arak Medical Sciences University, Arak
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.114488

Rights and Permissions


Disturbed sleep is common in end-stage renal disease (ESRD). Exogenous melatonin has somniferous properties in normal subjects and can improve sleep quality (SQ) in several clinical conditions. Recent studies have shown that melatonin may play a role in improving sleep in patients undergoing dialysis. The goal of the present study was to assess the effect of exogenous melatonin administration on SQ improvement in daytime hemodialysis patients. Lipid profile and the required dose of erythropoietin (EPO) are also reported as secondary outcomes. In a 6-week randomized, double-blind cross-over clinical trial, 3 mg melatonin or placebo was administered to 68 patients at bedtime. A 72-h washout preceded the switch from melatonin to placebo, or vice versa. SQ was assessed by the Pittsburgh sleep quality index (PSQI). Sixty-eight patients completed the study protocol and were included in the final analysis. Melatonin treatment significantly improved the global PSQI scores ( P < 0.001), particularly subjective SQ ( P < 0.001), sleep efficiency ( P = 0.005) and sleep duration ( P < 0.001). No differences in sleep latency and daytime sleepiness were observed. Melatonin also increased the high-density lipoprotein (HDL) cholesterol ( P = 0.003). The need for EPO prescription decreased after melatonin treatment ( P < 0.001). We conclude that melatonin can improve sleep in ESRD. The modest increase in HDL cholesterol and decrease in the EPO requirement are other benefits associated with this treatment

Keywords: End-stage renal disease, hemodialysis, melatonin, pittsburgh sleep quality index, sleep

How to cite this article:
Edalat-Nejad M, Haqhverdi F, Hossein-Tabar T, Ahmadian M. Melatonin improves sleep quality in hemodialysis patients. Indian J Nephrol 2013;23:264-9

How to cite this URL:
Edalat-Nejad M, Haqhverdi F, Hossein-Tabar T, Ahmadian M. Melatonin improves sleep quality in hemodialysis patients. Indian J Nephrol [serial online] 2013 [cited 2021 Aug 2];23:264-9. Available from:

  Introduction Top

Poor sleep quality (SQ) is common among patients on maintenance hemodialysis (HD). [1],[2],[3] SQ is important not only as a predictor of quality of life but also as a mortality risk among these patients. [4],[5] Evidence is not conclusive about the source of sleep disturbance in these patients. However, absence of a nocturnal rise in melatonin concentration in daytime HD patients has been documented, [6] suggesting that it may be related to the degree of chronic kidney disease. [7] In contrast, some studies on HD patients have shown a relationship between supra-physiological concentrations of melatonin and its major metabolite, 6-sulfatoxymelatonin, with a diurnal rhythm in spite of insomnia, delayed sleep onset, night-time arousals and restless-leg syndrome. [8] Also, a small non-randomized trial showed significant improvements in subjective and objective sleep parameters as well as partial recovery of nocturnal melatonin rhythm after switching to in-center nocturnal HD. [9] However, other studies have shown that despite recovery of the melatonin rhythm after nocturnal HD, patients still suffered from poor sleep. [10]

Recent studies have underlined the benefit of exogenous administration of melatonin in sleep disorders in many conditions such as old adult insomnic, [11] parkisonism, [12] asthma, [13] chronic obstructive pulmonary disease (COPD) [14],[15] and HD patients. [16] Also, there is a promising prospect that administration of melatonin could improve anti-oxidative defence and the lipid profile. [17],[18],[19]

The primary aim of this study is to investigate the efficacy of oral melatonin in improving quality of sleep in our patients on conventional daytime HD. In addition, lipid profile changes and erythropoietin (EPO) dose required after melatonin treatment are also evaluated.

  Materials and Methods Top

Study design and protocol

This was a randomized, double-blind cross-over clinical trial [Figure 1] to evaluate the effectiveness of melatonin versus placeboin improving SQ in HD patients. The research project was approved by the Human Research Ethics Committee of the Arak University of Medical Sciences in Iran and was registered at Iranian Registry of Clinical Trials with the registration number IRCT 201108077253N1.
Figure 1: Study design

Click here to view

Patients were screened for inclusion in the study by their SQ score base on the Pittsburgh Sleep Quality Index (PSQI). [20] Inclusion criteria were age >18 years, ability to give informed consent, duration of HD >3 months, PSQI score ≥5 and adherence to regular and steady dialysis program or medication that interfere with melatonin secretion (such as beta adreno-receptors blocking drug). Exclusion criteria included known major illness (malignancy, active infection and uncontrolled heart failure), pregnancy, iron deficiency anemia, poor control diabetes mellitus (hemoglobin A 1c >7.5), current use of melatonin or known allergy of melatonin, acute medical or surgical condition that required hospitalization or operation throughout the study and dementia or psychotic disorder as diagnosed by researchers that interferes with patient's participation in this trial. All patients received daytime dialysis, and the total hours per week varied from 8 to 11.5 h.

One hundred and nineteen out of 163 patients consented to fill out the PSQI questionnaire. Eighty-seven cases (73%) had PSQI score ≥5. Finally, 82 patients who met the inclusion criteria were enrolled in this trial. Patients were randomly assigned to placebo or melatonin for 6 weeks. Melatonin (Melatonin Plus) (Schiff® , Salt Lake City, USA) and placebo were packaged in identical 3-mg tablets. Melatonin plus has added Theanine, a natural compound found in green tea and vitamin B6 (10 mg). Dosage was set as one tablet taken at bedtime. After 6 weeks, patients underwent a 3-day washout period, followed by 6 weeks of the alternative therapy (from melatonin to placebo, and vice versa). Compliance was confirmed by pill count.

Measurement of sleep quality

SQ was measured using the PSQI. This 19-question questionnaire measures the SQ for the previous month. This questionnaire assesses seven components (each scored from 0 to 3) of subjective SQ, sleep efficiency, sleep disturbance, sleep latency, sleep duration, use of sleep medications and daytime dysfunction. The global PSQI score is calculated over a range of values from 0 to 21 by adding up these seven component scores. A patient with a global PSQI score ≥5 was considered to be a bad sleeper. In this study, patients completed this questionnaire by themselves or received assistance from research nurses during HD. Patients completed the PSQI questionnaire at the beginning of study and after the 6 weeks treatment by drug or placebo. The initial PSQI questionnaire score (W0) was used to determine eligibility to participate in the study (PSQI score ≥5).

Laboratory methods

Blood samples were collected prior to the HD session. Samples for complete blood count (CBC) were collected every 3 weeks and for total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol were collected at the beginning and at the end of the study in each arm.

EPO (PooyeshDarou-Poetin® , Tehran, Iran) was injected subcutaneously. Serum hemoglobin were measured every 3 weeks and used for EPO dose adjustment. Dose adjustment was done base on the patient's hemoglobin (Hgb) level, the target Hgb level, the observed rate of increase in Hgb level and the clinical circumstances, as recommended by the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) guidelines. [21] Injected EPO value was assessed by reviewing the dialysis charts and asking from patients. Cumulative prescribed EPO within 6 weeks, and also required dose at the end of 6 weeks of treatment by drug/placebo, were used to compare the drug/placebo effects in each arm.

Statistical analyses

Statistical analysis was performed using Statistical Package for the Social Sciences SPSS 17.0 and two-sample paired-group t test. The primary end point was the change in PSQI scores at the end of 6 weeks treatment of melatonin or placebo. Pre-defined secondary end points were the change in lipid profile parameters (HDL cholesterol, LDL cholesterol, triglyceride), hemoglobin and EPO dose required in proportional of hemoglobin in each arm. Upon completion of the study, primary and secondary end points were evaluated for all patients using a 95% significance criterion (P < 0.05).

  Results Top

Demographic data

Eighty-two consenting patients randomly took placebo or melatonin. During the course of the study, a total of 14 patients were withdrawn for reasons explained in [Table 1]. Sixty-eight patients (53% men; mean age of 58 ± 14 years; vintage of 6-296 months and 43% diabetics) remained in the study until completion. The majority of the subjects received HD for 4 h, three times a week. Baseline patient characteristics are shown in [Table 2].
Table 1: The causes of excluding 14 patients throughout the study period

Click here to view
Table 2: Baseline lipid profile and hemoglobin level of the study population (n= 68)

Click here to view

Baseline global and component PSQI scores and lab results

The baseline, mean global PSQI score of the patients was 10.58 ± 3.44 (95% Confidence Interval, 9.19-11.97). The baseline lipid profile and hemoglobin value of the sample is shown in [Table 2].

Effect of melatonin on sleep

PSQI scores were calculated at the end of 6 weeks. Significant improvements in global scores were observed in the melatonin-treated arm. Also, there was a statistically significant drop in the scores of sleep duration, sleep disturbance and sleep efficiency. In spite of improvement of subjective SQ, there was no improvement in daytime dysfunction after drug treatment. There was no meaningful difference in need for hypnotic sleep medications between groups. The global PSQI score and its components at the end of treatment are shown in [Table 3]. No significant differences were observed in PSQI scores by age, gender, time on HD or presence of diabetes (P > 0.05) (data not shown). There were also no serious detectable side-effects after melatonin treatment.
Table 3: Comparison of sleep quality in melatonin-treated and placebo groups

Click here to view

Effect of melatonin on lipid profile

There was no change in serum total cholesterol, LDL cholesterol and serum triglyceride levels throughout the study period [Table 4]. However, compared with the placebo, melatonin increased HDL cholesterol at the end of week 6 (P0 = 0.003).
Table 4: Comparison of lipid profile in melatonin-treated and placebo groups

Click here to view

Effect of melatonin on hematocrit and EPO dosage

There was no significant change in hemoglobin levels throughout the study period in both the drug treated and the placebo group [Table 5]. However, given the hemoglobin level, melatonin treatment decreased EPO dosage requirement.
Table 5: Comparison of hemoglobin values and erythropoietin requirement in melatonin-treated and placebo groups

Click here to view

There were also no statistically significant changes in either serum phosphorous, calcium-phosphorous product, serum parathyroid hormone or ferritin levels in both groups (P > 0.05) (data not shown).

  Discussion Top

Melatonin is found widely in nature, ranging from unicellular organisms, plants and fungi to animals and humans. [22] In the human body, melatonin is secreted nocturnally by the pineal gland as an endogenous sleep regulator. [22] Various studies have supported the effectiveness of exogenous melatonin in sleep disorders, [12],[13],[14],[15] insomnia, [11],[19] metabolic syndrome, [23] blood pressure regulation, [18],[24],[25] neurodegenerative diseases [11] and disorders of oxidative damage. [17],[18] As complaints on poor quality of sleep are common among HD patients, we proposed to examine the effect of endogenous melatonin on SQ in these patients. In a meta-analysis, Brzezinski et al.,[26] using information derived from 17 different studies (involving 284 subjects) studied sleep-onset latency, total sleep duration and sleep efficiency. They reported that melatonin treatment can significantly improve these sleep components. However, the magnitude of this effect appears to be clinically insignificant.

Another meta-analysis by Braam et al.,[27] used nine different studies including a total of 183 individuals with intellectual disabilities. The study concluded that melatonin was effective in increasing the total sleep time and reducing the sleep latency and the number of wakes per night in patients.

In contrast, meta-analysis of the effects of melatonin in sleep disturbances, including all age groups (six randomized controlled trials with 97 participants) conducted by Buscemi et al., [28] failed to document significant and clinically meaningful effects of exogenous melatonin on SQ, efficiency or latency. According to this analysis, melatonin did not have any effect on sleep-onset latency and sleep efficiency, SQ, wakefulness after sleep onset and the total sleep time in people with primary insomnia.

A recent study by Koch et al., [16] suggests that melatonin may lead to an improvement of subjective and objective sleep parameters in HD patients. Using the sleep questionnaire and actigraphy, the study assessed the effect of melatonin (6 weeks melatonin 3 mg) on SQ in 20 HD patients. It concluded that melatonin treatment can significantly improve objective sleep-onset latency, sleep efficiency and actual sleep time.

Our survey was similar to that of Koch et al., [16] except that we used only the PSQI questionnaire for assessment of SQ with a much larger sample size. Our data showed that 6-week melatonin administration improved patient-reported quality of sleep, particularly in terms of duration, disturbance and efficiency, without any impact on sleep latency and daytime dysfunction. Also, treatment with melatonin did not decrease the post-treatment need for sleep-inducing medication or hypnotics. Our results are different from those of Koch et al., [16] where they have shown a significant improvement in sleep latency. Most studies on the effect of melatonin on SQ have failed to show any profound improvement on daytime sleepiness except the studies by Garfinkel et al., [19] and Lemoin et al. [11] Both these studies stress the positive effect of melatonin on decreasing daytime sleepiness. Our results do not indicate any improvement in daytime dysfunction as reported by patients. Our results corroborate the findings by Nunes et al., [14] indicating no change in daytime sleepiness despite significant improvement in global PSQI scores, sleep latency and sleep duration in COPD. In our view, the differences in findings in various studies could be explained by the variations in the duration, administered dose, sample size, heterogeneity of the selected samples and the way in which outcomes were measured.

In our study, we also monitored the lipid profile of patients after 6 weeks of melatonin or placebo prescription. Our data demonstrated significant increases in HDL cholesterol levels ( P < 0.003) after melatonin treatment. In contrast, Garfinkel et al., [19] showed no significant changes in lipid profile after 3 weeks of melatonin (2 mg) treatment in 36 type 2 diabetic patients with insomnia. Meanwhile, Koziróg et al.,[18] suggest that melatonin can decrease the LDL cholesterol without any change in HDL cholesterol in patients with metabolic syndrome.

The significant decrease in EPO dose requirements is another positive outcome associated with melatonin use in HD patients. We were unable to find any references in regards to this finding in the published literature. However, a longer follow-up period and a higher number of patients are required to really obtain data with a higher statistical power. We speculate that our results may in part be due to the anti-oxidative effect of melatonin. Herrera et al., [17] have shown that oral consumption of melatonin can prevent oxidative stress of intravenous iron and EPO, both commonly used to treat anemia in chronic HD patients. Karimungi et al., [29] demonstrated diurnal sensitivity in melatonin-induced hematological changes in the male albino rat. They concluded that melatonin may have a modulatory role in hematopoiesis and its rhythms.

In our study, we also attempted to control for known potential confounding variables for quality of sleep, such as major comorbidity, overt mood disorders and changes in treatment protocol, which could typically induce major changes in the target biochemical parameters (glucose, phosphorous, etc.,) However, several limitations of this report should be noted. The main limitation of this study is the absence of polysomniography or actigraphy, without which it is not possible to ascertain the exact cause of insomnia and sleep disturbance. [30] Also, subjective reports of SQ do not have a single criterion standard.

The results from the present study, showing sleep improvement and possible beneficial effect on hematopoiesis, are promising. However, this study had a relatively small sample size and a short investigation period. A longer-term multicenter study with a larger sample will be needed to further confirm the benefits of exogenous melatonin in HD patients in the future.

  Conclusions Top

Our study suggests that melatonin may emerge as a safe, low-cost therapy for improving SQ in HD patients. The modest increase in HDL value and a decrease in the required EPO dose could be the other benefits of this treatment.

  Acknowledgment Top

The authors deem it is necessary to offer their thanks and appreciation to the Vice Chancellor for Research of the Arak University of Medical Sciences for providing the financial and logistical resources. They would also like to thank the very generous staff at Vali-Asr Hospital and the patients who participated in this clinical trial and gave them tremendous help and support in this study.

  References Top

1.Parker KP. Sleep disturbances in dialysis patients. Sleep Med Rev 2003;7:131-43.  Back to cited text no. 1
2.Merlino G, Piani A, Dolso P, Adorati M, Cancelli I, Valente M, et al. Sleep disorders in patients with end-stage renal disease undergoing dialysis therapy. Nephrol Dial Transplant 2006;21:184-90.  Back to cited text no. 2
3.Chiu YL, Chuang YF, Fang KC, Liu SK, Chen HY, Yang JY, et al. Higher systemic inflammation is associated with poorer sleep quality in stable haemodialysis patients. Nephrol Dial Transplant 2009;24:247-51.  Back to cited text no. 3
4.Iliescu EA, Coo H, McMurray MH, Meers CL, Quinn MM, Singer MA, et al. Quality of sleep and health-related quality of life in haemodialysis patients. Nephrol Dial Transplant 2003;18:126-32.  Back to cited text no. 4
5.Elder SJ, Pisoni RL, Akizawa T, Fissell R, Andreucci VE, Fukuhara S, et al. Sleep quality predicts quality of life and mortality risk in haemodialysis patients: Results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2008;23:998-1004.  Back to cited text no. 5
6.Viljoen M, Steyn ME, van Rensburg BW, Reinach SG. Melatonin in chronic renal failure. Nephron 1992;60:138-43.  Back to cited text no. 6
7.Koch BC, van der Putten K, Van Someren EJ, Wielders JP, Ter Wee PM, Nagtegaal JE, et al. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study). Nephrol Dial Transplant 2010;25:513-9.  Back to cited text no. 7
8.Koch BC, Hagen EC, Nagtegaal JE, Boringa JB, Kerkhof GA, Ter Wee PM. Effects of nocturnal hemodialysis on melatonin rhythm and sleep-wake behavior: An uncontrolled trial. Am J Kidney Dis 2009;53:658-64.  Back to cited text no. 8
9.Koch BC, Nagtegaal JE, Hagen EC, Wee PM, Kerkhof GA. Different melatonin rhythms and sleep-wake rhythms in patients on peritoneal dialysis, daytime hemodialysis and nocturnal hemodialysis. Sleep Med 2010;11:242-6.  Back to cited text no. 9
10.Lüdemann P, Zwernemann S, Lerchl A. Clearance of melatonin and 6-sulfatoxymelatonin by hemodialysis in patients with end-stage renal disease. J Pineal Res 2001;31:222-7.  Back to cited text no. 10
11.Lemoine P, Nir T, Laudon M, Zisapel N. Prolonged-release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects. J Sleep Res 2007;16:372-80.  Back to cited text no. 11
12.Medeiros CA, Carvalhedo de Bruin PF, Lopes LA, Magalhães MC, de Lourdes Seabra M, de Bruin VM. Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson's disease. A randomized, double blind, placebo-controlled study. J Neurol 2007;254:459-64.  Back to cited text no. 12
13.Campos FL, da Silva-Júnior FP, de Bruin VM, de Bruin PF. Melatonin improves sleep in asthma: A randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med 2004;170:947-51.  Back to cited text no. 13
14.Nunes DM, Mota RM, Machado MO, Pereira ED, Bruin VM, Bruin PF. Effect of melatonin administration on subjective sleep quality in chronic obstructive pulmonary disease. Braz J Med Biol Res 2008;41:926-31.  Back to cited text no. 14
15.Shilo L, Dagan Y, Smorjik Y, Weinberg U, Dolev S, Komptel B, et al. Effect of melatonin on sleep quality of COPD intensive care patients: A pilot study. Chronobiol Int 2000;17:71-6.  Back to cited text no. 15
16.Koch BC, Nagtegaal JE, Hagen EC, van der Westerlaken MM, Boringa JB, Kerkhof GA, et al. The effects of melatonin on sleep-wake rhythm of daytime haemodialysis patients: A randomized, placebo-controlled, cross-over study (EMSCAP study). Br J Clin Pharmacol 2009;67:68-75.  Back to cited text no. 16
17.Herrera J, Nava M, Romero F, Rodríguez-Iturbe B. Melatonin prevents oxidative stress resulting from iron and erythropoietin administration. Am J Kidney Dis 2001;37:750-7.  Back to cited text no. 17
18.Koziróg M, Poliwczak AR, Duchnowicz P, Koter-Michalak M, Sikora J, Broncel M. Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome. J Pineal Res 2011;50:261-6.  Back to cited text no. 18
19.Garfinkel D, Zorin M, Wainstein J, Matas Z, Laudon M, Zisapel N. Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: A randomized, double-blind, crossover study. Diabetes Metab Syndr Obes 2011;4:307-13.  Back to cited text no. 19
20.Buysse DJ, Reynolds CF 3 rd , Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213.  Back to cited text no. 20
21.KDOQI, National Kidney Foudnation. II. Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease in adults. Am J Kidney Dis 2006;47(Suppl 3):S16-85.  Back to cited text no. 21
22.Macchi MM, Bruce JN. Human pineal physiology and functional significance of melatonin. Front Neuroendocrinol 2004;25:177-95.  Back to cited text no. 22
23.Cardinali DP, Cano P, Jiménez-Ortega V, Esquifino AI. Melatonin and the metabolic syndrome: Physiopathologic and therapeutical implications. Neuroendocrinology 2011;93:133-42.  Back to cited text no. 23
24.Scheer FA, Van Montfrans GA, van Someren EJ, Mairuhu G, Buijs RM. Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension. Hypertension 2004;43:192-7.  Back to cited text no. 24
25.Arangino S, Cagnacci A, Angiolucci M, Vacca AM, Longu G, Volpe A, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol 1999;83:1417-9.  Back to cited text no. 25
26.Brzezinski A, Vangel MG, Wurtman RJ, Norrie G, Zhdanova I, Ben-Shushan A, et al. Effects of exogenous melatonin on sleep: A meta-analysis. Sleep Med Rev 2005;9:41-50.  Back to cited text no. 26
27.Braam W, Smits MG, Didden R, Korzilius H, Van Geijlswijk IM, Curfs LM. Exogenous melatonin for sleep problems in individuals with intellectual disability: A meta-analysis. Dev Med Child Neurol 2009;51:340-9.  Back to cited text no. 27
28.Buscemi N, Vandermeer B, Hooton N, Pandya R, Tjosvold L, Hartling L, et al. Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: Meta-analysis. BMJ 2006;332:385-93.  Back to cited text no. 28
29.Karimungi MG, Joshi BN. Diurnal sensitivity in melatonin-induced hematological changes in the male albino rat. Biol Signals 1996;5:283-90.  Back to cited text no. 29
30.Morgenthaler T, Alessi C, Friedman L, Owens J, Kapur V, Boehlecke B, et al. Practice parameters for the use of actigraphy in the assessment of sleep and sleep disorders: An update for 2007. Sleep 2007;30:519-29.  Back to cited text no. 30


  [Figure 1]

  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]

This article has been cited by
1 Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment: which might be a more promising strategy for ICU sleep deprivation?
Hua-Wei Huang,Bo-Lu Zheng,Li Jiang,Zong-Tong Lin,Guo-Bin Zhang,Ling Shen,Xiu-Ming Xi
Critical Care. 2015; 19(1)
[Pubmed] | [DOI]
2 Impact of oral melatonin on critically ill adult patients with ICU sleep deprivation: study protocol for a randomized controlled trial
Huawei Huang,Li Jiang,Ling Shen,Guobin Zhang,Bo Zhu,Jiajia Cheng,Xiuming Xi
Trials. 2014; 15(1): 327
[Pubmed] | [DOI]


Print this article  Email this article


Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07