IgA dominant postinfectious glomerulonephritis: Report of two cases

V Rajakumar; S. A. K. Noor Mohamed; AA Kurien; ME Fernando

doi:10.4103/0971-4065.132020

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CASE REPORT

Year : 2014 | Volume : 24 | Issue : 3 | Page : 181-184

IgA dominant postinfectious glomerulonephritis: Report of two cases

V Rajakumar¹, S. A. K. Noor Mohamed¹, AA Kurien², ME Fernando¹
¹ Department of Nephrology, Government Stanley Medical College, Chennai, Tamil Nadu, India
² Department of Anatomical Pathology and Cytopathology, Madras Medical Mission, Chennai, Tamil Nadu, India

Correspondence Address:
V Rajakumar
Department of Nephrology, Government Stanley Hospital, Chennai - 600 001, Tamil Nadu
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0971-4065.132020

Immunoglobulin A (IgA) dominant postinfectious glomerulonephritis (IgA PIGN) is a distinct clinical entity increasingly recognized in adult. It usually presents with reduced glomerular filtration rate, heavy proteinuria, and has unfavorable prognosis. Immunofluorescence study of renal biopsy specimens have IgA as dominant or codominant antibody. We encountered two cases of IgA dominant PIGN recently presenting as rapidly progr essive glomerulonephritis and managed conservatively. Both the patients are on follow-up and do not have complete recovery of renal function till date. Long-term follow-up is needed to assess the progression of the disease in these patients.

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