| ORIGINAL ARTICLE
|Year : 2014 | Volume
| Issue : 4 | Page : 226-231
Renal histology in diabetic nephropathy: "A novel perspective"
M Sahay1, RK Mahankali1, K Ismal1, PS Vali1, RK Sahay2, G Swarnalata3
1 Department of Nephrology, Osmania General Hospital and Medical College, Hyderabad, Andhra Pradesh, India
2 Department of Endocrinology, Osmania General Hospital and Medical College, Hyderabad, Andhra Pradesh, India
3 Department of Pathology, Apollo Hospitals, Hyderabad, Andhra Pradesh, India
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease all over the world. India has a high incidence and prevalence of diabetes and >30% have nephropathy. Recently, a histological classification has been proposed. This study analyzed the renal histology in 114 diabetic patients with renal dysfunction. Nearly 75% of patients had DN. Fifty five (63.95%) were males. Mean duration of diabetes was 7.04 ± 4.9 years. Mean serum creatinine in study group was 5.2 ± 2.9 mg/dl, with mean estimated glomerular filtration rate of 23.43 ± 21.48 ml/min/1.732 m 2 . Forty eight patients (55.81%) had diabetic retinopathy (DR); prevalence of DR was more in patients who had diabetes for > 10 years than patients who had diabetes for <6 years (P = 0.022). The most common histological class was Class IV observed in 37 (43.02. %) cases, Class III DN in 24 (27.90%) cases, Class IIa and Class IIb in 11 (12.79%) cases each and Class I DN in 3 (3.48%) cases. Higher histological class was associated with higher proteinuria, lower glomerular filtration rate (P < 0.001) and was more likely to be associated with retinopathy (P = 0.012) and hypertension (P = 0.0003) but did not correlate with duration of diabetes (P = 0.85). There was a poor correlation between retinopathy and DN. Biopsy helps to stage the renal lesions in diabetics with renal dysfunction.
Department of Nephrology, Osmania General Hospital and Medical College, Hyderabad, Andhra Pradesh
Source of Support: None, Conflict of Interest: None
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