Monoclonal gammopathy associated membranous glomerulonephritis: A rare entity

KK Gowda; K Joshi; R Ramachandran; R Nada

doi:10.4103/0971-4065.135353

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CASE REPORT

Year : 2015 | Volume : 25 | Issue : 1 | Page : 50-53

Monoclonal gammopathy associated membranous glomerulonephritis: A rare entity

KK Gowda¹, K Joshi¹, R Ramachandran², R Nada¹
¹ Department of Histopathology, PGIMER, Chandigarh, India
² Department of Nephrology, PGIMER, Chandigarh, India

Correspondence Address:
R Nada
Department of Histopathology, PGIMER, Chandigarh
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/0971-4065.135353

A 40-year-old male presented with nephrotic syndrome. Light microscopic analysis of the renal biopsy showed thickening of the glomerular capillary wall. Immunofluorescence examination revealed granular deposition of monoclonal immunoglobulin (Ig) G3-kappa and complement C3 along the glomerular basement membrane. Electron microscopy showed subepithelial electron dense deposits, thus confirming membranous glomerulonephritis (MGN) with monoclonal gammopathy. MGN with monoclonal gammopathy is an extremely rare but distinctive entity. This patient was treated with a combination of bortezomib, thalidomide and dexamethasone and showed partial remission of his nephrotic state and dysproteinemia.

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