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Year : 2015  |  Volume : 25  |  Issue : 4  |  Page : 237-241

Daily postdilutional hemodiafiltration with FX800 polysulfone dialyzers for removing kappa light chains in multiple myeloma-induced kidney injury

Nephrologisches Zentrum Emsdetten, Nordwalderstr, 48-50, D-48282 Emsdetten, Germany

Correspondence Address:
F P Tillmann
Nephrologisches Zentrum Emsdetten, Nordwalderstrasse 48-50 D-48282 Emsdetten
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0971-4065.158176

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Multiple myeloma is an increasing cause of renal failure in the elderly. Early diagnosis of myeloma-associated acute renal failure is paramount and rapid initiation of disease-specific treatments with a combination of chemotherapy and dialytic therapies for instant removal of free light chains have been proposed. For immediate light chain removal, high cut-off dialyzers have been reported to yield superior light chain clearance parameters, but these dialyzers are not widely used due to increased treatment costs. In addition, the clinical virtue of hemodiafiltration (HDF) has not yet been definitively determined. We hereby present the case of a 70-year-old female patient with kappa light chain myeloma and acute on chronic renal failure. Daily HDF for 1-week using standard polysulfone high-flux dialyzers was implemented and led to remarkable and effective light chain reduction ratios between 87% and 95%.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07