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 ORIGINAL ARTICLE
Year : 2016  |  Volume : 26  |  Issue : 6  |  Page : 419-422

Effect of Ferula assa-foetida oleo-gum-resin on renal function in normal Wistar rats


1 Department of Physiology/Herbal Medicine Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Natural Resources and Watershed, Tabas, Iran

Correspondence Address:
S M Bagheri
Department of Physiology, Shahid Sadoughi University of Medical Sciences, Prof. Hesabi Bulvd., Shohadaye Gomnam Bulvd., 8915173149, Yazd
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-4065.171245

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In traditional Iranian medicine, asafoetida, an oleo-gum-resin obtained from the roots of Ferula assa-foetida, has been prescribed as a diuretic. This study was undertaken to investigate the diuretic effect of asafoetida in normal rats. Asafoetida was administered orally at the doses of 25 and 50 mg/kg and furosemide (10 mg/kg, intraperitoneal) was used as positive control. The diuretic effect was evaluated by measuring urine volume and sodium, potassium, urea, and creatinine content in urine and serum. Urine volume, excretion of sodium, and potassium were significantly increased by asafoetida as compared to the control group. A significant increase in creatinine clearance was observed in the groups treated with asafoetida at the doses of 25 and 50 mg/kg (P < 0.05). We conclude that asafoetida induced a diuretic effect comparable to that produced by the reference diuretic furosemide. This study provides a quantitative basis for explaining the folkloric use of asafoetida as a diuretic agent.






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Indian Journal of Nephrology
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Online since 20th Sept '07