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 CASE REPORT
Year : 2017  |  Volume : 27  |  Issue : 6  |  Page : 482-483

Trimethoprim-sulfamethoxazole-induced hepatotoxicity in a renal transplant patient


1 Department of Gastroenterology, Hotel-Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon
2 Department of Nephrology, Hotel-Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon

Correspondence Address:
R Slim
Department of Gastroenterology, Hotel-Dieu de France Hospital, Achrafieh, Beirut
Lebanon
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijn.IJN_339_16

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Drug-induced liver injury (DILI) represents liver damage from various therapeutic drugs. Antimicrobials are among the most common causes of DILI. We report a case of hepatic toxicity due to Trimethoprim-sulfamethoxazole (TMP-SMX) in a patient who underwent renal transplantation. Diagnosis has been made after a careful history taking, exclusion of competing etiologies and reversal of biochemical abnormalities after withdrawal of the antibiotic. TMP-SMX liver toxicity is well known but remains unpredictable and is rarely reported.






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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07