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Year : 2021  |  Volume : 31  |  Issue : 3  |  Page : 293-295

An unusual neurological syndrome in a haemodialysis patient

1 Department of Nephrology, SRIHER, Porur, Tamil Nadu, India
2 Department of Nephrology, SRMIST, Kattankulathur, Tamil Nadu, India

Correspondence Address:
Dr. V Jayaprakash
Department of Nephrology, SRMIST, Kattankulathur, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_11_20

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Advanced age and immunosuppressed states allow for complications of herpes zoster such as encephalitis. In this case report, we describe a patient with encephalopathy two days after initiation of antiviral therapy. After the necessary imaging and cerebrospinal fluid (CSF) analysis, it became evident that the neurological syndrome was due to acyclovir. Despite currently practised renal dose modification, the patient developed acyclovir-induced neurotoxicity and required intensification of his dialysis schedule to eliminate the drug. Acyclovir-induced neurotoxicity is a rare clinical presentation and presents a clinical dilemma to the physician who has to distinguish this entity from herpes zoster encephalitis and posterior circulation stroke.


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Indian Journal of Nephrology
Published by Wolters Kluwer - Medknow
Online since 20th Sept '07