|Year : 2022 | Volume
| Issue : 4 | Page : 327-333
Diabetes and mortality among patients with chronic kidney disease and COVID-19: A systematic review, meta-analysis, and meta-regression
Maria R Iryaningrum1, Rudi Supriyadi2, Sherly Lawrensia3, Joshua Henrina4, Nanny Natalia M. Soetedjo5
1 Department of Internal Medicine, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia
2 Department of Internal Medicine, Division of Nephrology and Hypertension, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia
3 Department of Medicine, Regional Public Hospital of Waikabubak, Tangerang, Indonesia
4 Department of Medicine, Balaraja Public Health Centre, Tangerang, Indonesia
5 Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran – Dr Hasan Sadikin Hospital, Bandung, Indonesia
|Date of Submission||08-Jul-2021|
|Date of Acceptance||10-Oct-2021|
|Date of Web Publication||20-May-2022|
Maria R Iryaningrum
Address: Jl. Pluit Raya No. 2, RT.21/RW.8, Penjaringan, Kec. Penjaringan, Kota Jakarta Utara, Daerah Khusus Ibukota Jakarta - 14440
Source of Support: None, Conflict of Interest: None
Introduction: Patients with kidney disease and COVID-19, whether on hemodialysis (HD) or not, have a higher risk of contracting COVID-19 accompanied by a higher mortality rate due to suppressed immune functions. Diabetes, one of the ubiquitous etiology of kidney disease, is also associated with a composite of poor outcomes. Methods: Meta-analysis and meta-regression of 13 articles on COVID-19 patients with chronic kidney disease, with information on diabetes and mortality were performed using Review Manager 5.4 and OpenMetaAnalyst. Results: The meta-analysis of a pooled subject of 18,822 patients showed that the presence of diabetes in CKD patients with COVID-19 was associated with an increased risk of mortality (RR 1.41 (1.15, 1.72); P < 0.001; I2 70%, P < 0.001). Subgroup analysis showed that diabetes was not associated with mortality in the HD group (RR 1.27 (1.06, 1.54); P = 0.01; I2 0%, P = 0.70) but showed a significant association in the non-HD group (RR 1.66 (1.59, 1.73); P < 0.001; I2 85%, P < 0.001). Male gender (P = 0.070) contributed to the effect size differences (age: P < 0.001; hypertension: P = 0.007; CVD: P < 0.001; lung disease: P < 0.001). Conclusions: Diabetes was associated with higher mortality risk among CKD patients, primarily those who did not need RRT.
Keywords: Chronic kidney disease, COVID-19, diabetes, hemodialysis
|How to cite this article:|
Iryaningrum MR, Supriyadi R, Lawrensia S, Henrina J, M. Soetedjo NN. Diabetes and mortality among patients with chronic kidney disease and COVID-19: A systematic review, meta-analysis, and meta-regression. Indian J Nephrol 2022;32:327-33
|How to cite this URL:|
Iryaningrum MR, Supriyadi R, Lawrensia S, Henrina J, M. Soetedjo NN. Diabetes and mortality among patients with chronic kidney disease and COVID-19: A systematic review, meta-analysis, and meta-regression. Indian J Nephrol [serial online] 2022 [cited 2022 Aug 9];32:327-33. Available from: https://www.indianjnephrol.org/text.asp?2022/32/4/327/345253
| Introduction|| |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has persisted as a major worldwide public health challenge since its emergence in December 2019 in Wuhan, China. As of May 21, 2020, more than 160 million people infected with more than three million died due to coronavirus disease of 2019 (COVID-19). Although vaccination rollouts are still being held worldwide, COVID-19's mortality rate still keeps increasing, mainly attributed to underserved communities, more common in low and middle-income countries (LMICs).
It is well known that patients with comorbidities are disproportionately affected by COVID-19 and associated with a grim prognosis. It is well-established that advanced age and various comorbidities, such as hypertension, diabetes mellitus, chronic kidney disease (CKD), stroke, dementia, and older age, are independently associated with a higher mortality rate when infected with COVID-19.[4–8] Charlson comorbidity index (CCI), an easy-to-use clinical prediction tool to predict the mortality risk in patients with comorbidities, showed that a per-point increase in the CCI score in COVID-19 patients was associated with a 16% increase in mortality risk.
There is no exception for patients with CKD and COVID-19. Whether on hemodialysis (HD) or not, CKD patients have a higher risk of contracting COVID-19 accompanied by a higher mortality rate due to suppressed immune functions. Moreover, diabetes, one of the ubiquitous etiology of CKD, is also associated with a poor composite outcomes.
Interestingly, several studies showed that diabetes did not significantly increase the risk of mortality among HD patients.[12–14] A study by Aoun et al. showed that multimorbidities, including heart failure, coronary artery disease (CAD) stroke, dementia, and older age, increased the risk of mortality in HD patients with COVID-19, but not diabetes. The European Renal Association COVID-19 Database (ERACODA) study consistently showed that diabetes was not a risk factor for mortality among dialysis and kidney transplant patients with COVID-19. Goicoechea also declared that diabetes was not associated with higher mortality in maintenance hemodialysis patients infected by COVID-19 (P = 0.475).
Therefore, contrasting evidence on the impact of DM in CKD patients, especially those who were on HD, needs to be investigated. To fill the evidence gap, we performed a systematic review and meta-analysis to delineate better the association between diabetes and mortality among patients with CKD and COVID-19.
| Methods|| |
We included articles enrolling COVID-19 patients with CKD with information on the presence of diabetes and mortality. We excluded case reports or case series with less than ten patients, review articles, commentaries, non-research letters, non-English language articles, and preprint articles to prevent the inclusion of fraudulent research.
Search strategy and study selection
We systematically searched literature from PubMed, EMBASE, and Europe PMC databases. Keywords used were “2019-nCoV” OR “COVD-19” OR “SARS-CoV-2” AND “Diabetes Mellitus” OR “Type 2 Diabetes Mellitus” OR “T2DM” OR “Diabetes” OR “Diabetic Nephropathy” OR “Diabetic Kidney Disease” OR “DKD” AND “Chronic Kidney Disease” OR “CKD” OR “End Stage Kidney Disease” OR “ESKD” OR “Chronic Renal Failure” OR “CRF” AND “Mortality” OR “Outcomes” up until March 31, 2021. After removal of duplicates, two authors independently screened the title and abstract of the records. The full-texts of remaining articles were evaluated by applying the inclusion and exclusion criteria. Any discrepancies were resolved through discussion and adjudicated by a third person. This study was carried out under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline.
We used a standardized form to collect all the information, including author, year, country, study design, sample size, age, gender, diabetes, hypertension, cardiovascular disease, and lung disease. The outcome of interest of this meta-analysis was mortality.
Risk of bias evaluation
We evaluated the risk of bias of included studies by using Joanna Briggs Institute Critical Appraisal Checklist [Table 1]. We assessed each study for its risk of bias according to its type of study. Each tool for cross-sectional study and case series consisted of eight and ten questions, respectively. Subsequently, we interpreted the overall evaluation of the bias assessment risk with low risk of bias, high risk of bias, or unclear. Studies with a suspected high risk of bias were excluded. We used the funnel plot graphic to assess the potency of publication bias.
|Table 1: Risk of bias assessment using Joanna Briggs Institute Critical Appraisal Checklist|
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Review Manager 5.4 (Cochrane Collaboration) and OpenMetaAnalyst (Brown University, RI, USA) were utilized to perform the meta-analysis and meta-regression, respectively.
We calculated the pooled estimates and its 95% confidence interval in the form of risk ratios (RRs) by using the Mantel–Haenszel formula to determine the association between dichotomous variables (DM and mortality). We used a random-effects model regardless of the heterogeneity to account for interstudy variability. We also used two-tailed P values with a significance set at ≤0.05. We did sensitivity analysis by a leave-one-out method to determine the source of heterogeneity and test the statistical robustness. We divided all studies into two subgroups (HD and non-HD) to analyze the association between DM and mortality from each group. Meta-regression was utilized to assess the covariates' influence on the effect size differences, including age, gender, hypertension, cardiovascular disease (CVD), and lung disease. Finally, we performed a funnel-plot analysis to assess the risk of publication bias qualitatively.
| Results|| |
We collected 13 studies: six observational studies, five retrospective studies, one case series, and one case report [Table 2].,,,,,,,,,,,, A total of 18,822 patients were included in the quantitative synthesis. [Figure 1] shows the study profile [Figure 1].
Diabetes and mortality
The meta-analysis with a pooled subject of 18,822 patients showed that the presence of diabetes in CKD patients with COVID-19 was associated with an increased risk of mortality (RR 1.41 (1.15, 1.72); P < 0.001; I2 70%, P < 0.001). Strikingly, subgroup analysis showed that diabetes was not associated with mortality in the HD group (RR 1.27 (1.06, 1.54); P = 0.01; I2 0%, P = 0.70) but showed a significant association in the non-HD group (RR 1.66 (1.59, 1.73); P < 0.001; I2 85%, P < 0.001) [Figure 2] and [Figure 3].
|Figure 2: Diabetes in chronic kidney disease (CKD) and mortality. The meta-analysis showed a significant association between diabetes in CKD and mortality|
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|Figure 3: Subgroup analysis among HD and non-HD patients. The meta-analysis showed a significant association in the non-HD group|
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The meta-regression showed that all covariates, but male gender (P = 0.070) contributed to the effect size differences (age: P < 0.001; hypertension: P = 0.007; CVD: P < 0.001; lung disease: P < 0.001). Furthermore, a multivariate meta-regression performed by including these significant covariates in a single analysis showed that none are significant, suggesting dependent nature between the covariates (age: P = 0.105; hypertension: P = 0.690; CVD: P: 0.366; lung disease: P = 0.731) [Figure 4].
|Figure 4: Meta-regression analysis showed that the association between diabetes and mortality in CKD was influenced by (a) gender, (b) hypertension, (CVD), and (d) lung disease|
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Funnel-plot diagram analysis showed a qualitatively asymmetrical funnel plot for the association between diabetes and mortality in CKD patients, indicating the presence of a publication bias [Figure 5].
|Figure 5: Publication bias analysis. The funnel plot showed a qualitatively asymmetrical funnel plot for the association between diabetes and mortality in CKD patients|
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| Discussion|| |
This meta-analysis supports previous studies regarding the risk factors of mortality in COVID-19 and showed that patients with COVID-19 were significantly higher in patients with diabetes and CKD than those in CKD without diabetes.
Patients with CKD are more susceptible to bacterial and viral infections due to the alterations of the immune system caused by excessive levels of pro-inflammatory cytokines and oxidative stress. Further, diabetic patients are also at risk of pneumonia due to the lung defense system dysfunction caused by a higher concentration of glucose in the alveolar surface liquid (ASL), imbalance of reactive oxygen species (ROS), and inflammatory chemokine production. Diabetic patients are also more susceptible to infections and are at excess risk for complications, morbidity, and mortality associated with these infections. Therefore, diabetes in combination with CKD may confer a greater chance of hypoxemia and severe hyperinflammation. Consequently, these vulnerabilities translate to poor outcomes.
Leon-Abarca et al. showed that diabetic kidney disease patients were more susceptible to be infected by SARS-CoV-2, had higher rates of getting pneumonia, mechanical intubation, ICU admission, and greater case-fatality rate. Gilbert et al. did a kidney biopsy among patients with diabetic kidney disease and COVID-19 and found a twofold higher angiotensin-converting enzyme (ACE) 2 messenger RNA level. This may increase the possibility of kidney infection, risk of AKI, and death. The accumulating body of evidence showed that renin-angiotensin-aldosterone-system (RAAS) blockers did not increase the risk of poor outcomes in COVID-19 patients and were even protective for HD patients.
In this meta-analysis, the subgroup analysis showed that diabetes in the HD group infected with COVID-19 was not associated with the increased risk of mortality. Consistently, this result was in line with other studies among HD patients with COVID-19., In contrast to non-COVID-19 patients, the presence of diabetes in HD patients increased the risk of death 1.9 fold compared to those without diabetes (95% CI: 1.25–2.89; P = 0.003), along with age, serum albumin, CAD, and vascular access as the independent predictors of mortality. A possible explanation for this phenomenon is an excess mortality risk in COVID-19 patients with CKD and DM. Still, it is equalized when the CKD stage progresses to ESKD, which mandates renal replacement therapy (RRT). This finding aligns with the multinational dialysis cohort analysis showing that diabetes was not a significant predictor of COVID-19 mortality. Therefore, a kidney protective strategy is needed to mitigate the elevated mortality risk faced by the DKD patients with COVID-19 who did not need RRT.
Importantly, in the form of HbA1C levels, long-term glucose monitoring in this group was shown to be important in a non-COVID-19 setting. A U-shaped curve of HbA1C levels was demonstrated in CKD patients with DM, with levels of <6.5% and >8.0% associated with higher mortality. This finding can be explained by malnutrition-inflammation syndrome and cachexia for HbA1C levels of <6.5%, which are rampant in these patients, and HbA1C levels of >8.0% were associated with microvascular and macrovascular complications of diabetes. On the contrary, the prognostic role of the HbA1C group is somewhat controversial in COVID-19 patients with diabetes in general.
Finally, we underscore the importance of comorbidities' impact on DKD patients, whether on hemodialysis or not. In line with other studies of CKD patients, primarily those on routine hemodialysis, our meta-analysis showed that the overall effect size of CKD patients' mortality was influenced by comorbidities and more severe in older patients.,, Understandably, our findings reflect on a frailer population, in which primary prevention through vaccination will play a crucial role.
There were some limitations in this study. First, most of the studies included in this meta-analysis were retrospective in nature, which precluded us from establishing a cause and effect relationship. Second, the overall effect size was driven mainly by the Parra–Bracamonte et al. study, with the most study subjects. Third, we did not divide the CKD groups into categories based on the glomerular filtration rate or CKD stages. Fourth, we did not analyze the effect of blood glucose controls and alterations and their influence on COVID-19 mortality in DKD patients as these data were not available in the included studies. Finally, we only included English language studies, which may have affected the number of studies included in this research. Finally, our meta-analysis findings need to be carefully interpreted because of the presence of publication bias.
| Conclusion|| |
This meta-analysis showed that diabetes was associated with higher mortality risk among CKD patients, primarily those who did not need RRT. Renal protective strategies are needed for these patients because intervention beyond this opportunity window may render them useless. Nevertheless, future studies with enrolling large subjects and prospective in nature are needed to confirm our findings in the future. Finally, as DKD patients with or without the need for RRT are frailer, vaccination should be the priority for this population.
The data used to support the findings of this study are included in the article.
Availability of data and materials
All data generated or analyzed during this study are included in this published article. The corresponding author (MRI) can be contacted for more information.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| References|| |
WHO. WHO Coronavirus (COVID-19) Dashboard. WHO Coronavirus (COVID-19) Dashboard With Vaccination Data. Who 2021:1–5.
Imam Z, Odish F, Gill I, O'Connor D, Armstrong J, Vanood A, et al
. Older age and comorbidity are independent mortality predictors in a large cohort of 1305 COVID-19 patients in Michigan, United States. J Intern Med 2020;288:469–76. https://doi.org/10.1111/joim0.13119
Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia – A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr Clin Res Rev 2020;14:395–403. https://doi.org/10.1016/j.dsx. 20200.04.018
July J, Pranata R. Prevalence of dementia and its impact on mortality in patients with coronavirus disease 2019: A systematic review and meta-analysis. Geriatr Gerontol Int 2021;21:172–7. https://doi.org/10.1111/ggi. 14107
de Almeida-Pititto B, Dualib PM, Zajdenverg L, Dantas JR, de Souza FD, Rodacki M, et al
. Severity and mortality of COVID 19 in patients with diabetes, hypertension and cardiovascular disease: a meta-analysis. Diabetol Metab Syndr 2020;12:75. https://doi.org/10.1186/s13098-020-00586-4
Tuty Kuswardhani RA, Henrina J, Pranata R, Anthonius Lim M, Lawrensia S, Suastika K. Charlson comorbidity index and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis. Diabetes Metab Syndr 2020;14:2103–9. https://doi.org/10.1016/j.dsx. 2020.10.022
Ozturk S, Turgutalp K, Arici M, Odabas AR, Altiparmak MR, Aydin Z, et al
. Mortality analysis of COVID-19 infection in chronic kidney disease, haemodialysis and renal transplant patients compared with patients without kidney disease: A nationwide analysis from Turkey. Nephrol Dial Transplant 2021;35:2083–95. https://doi.org/http://dx.doi.org/10.1093/NDT/GFAA271
Leon-Abarca JA, Memon RS, Rehan B, Iftikhar M, Chatterjee A. The impact of COVID-19 in diabetic kidney disease and chronic kidney disease: A population-based study. Acta Biomed 2020;91:e2020161. https://doi.org/10.23750/abm.v91i4.10380
Aoun M, Khalil R, Mahfoud W, Fatfat H, Bou Khalil L, Alameddine R, et al
. Age and multimorbidities as poor prognostic factors for COVID-19 in hemodialysis: a Lebanese national study. BMC Nephrol 2021;22:73. https://doi.org/10.1186/s12882-021-02270-9
Hilbrands LB, Duivenvoorden R, Vart P, Franssen CFM, Hemmelder MH, Jager KJ, et al
. COVID-19-related mortality in kidney transplant and dialysis patients: Results of the ERACODA collaboration. Nephrol Dial Transplant 2020;35:1973–83. https://doi.org/10.1093/ndt/gfaa261
Goicoechea M, Sánchez Cámara LA, Macías N, Muñoz de Morales A, Rojas ÁG, Bascuñana A, et al
. COVID-19: clinical course and outcomes of 36 hemodialysis patients in Spain. Kidney Int 2020;98:27–34. https://doi.org/10.1016/j.kint. 2020.04.031
Sİpahİ S, Dheİr H, ToÇoĞlu A, BektaŞ M, AÇikgÁz SBi, GenÇ ACi, et al
. Characteristics and Mortality Determinants of COVID-19 Patients Undergoing Haemodialysis. Turkish J Med Sci 2020. https://doi.org/10.3906/sag-2006-54
Stefan G, Mehedinti AM, Andreiana I, Zugravu AD, Cinca S, Busuioc R, et al
. Clinical features and outcome of maintenance hemodialysis patients with COVID-19 from a tertiary nephrology care center in Romania. Ren Fail 2021;43:49–57. https://doi.org/10.1080/0886022X0.2020.1853571
Fisher M, Yunes M, Mokrzycki MH, Golestaneh L. ESKD patients hospitalized with COVID-19: Early outcomes in Bronx, New York. J Am Soc Nephrol 2020;31:262.
Zou R, Chen F, Chen D, Xu CL, Xiong F. Clinical characteristics and outcome of hemodialysis patients with COVID-19: a large cohort study in a single Chinese center. Ren Fail 2020;42:950–7. https://doi.org/100.1080/0886022X.2020.1816179
Parra-Bracamonte GM, Parra-Bracamonte FE, Lopez-Villalobos N, Lara-Rivera AL. Chronic kidney disease is a very significant comorbidity for high risk of death in patients with COVID-19 in Mexico. Nephrology (Carlton) 2021;26:248–51. https://doi.org/10.1111/nep0.13827
Oliveira TL, Melo IS, Cardoso-Sousa L, Santos IA, El Zoghbi MB, Shimoura CG, et al
. Pathophysiology of SARS-CoV-2 in Lung of Diabetic Patients. Front Physiol 2020;11:587013. https://doi.org/100.3389/fphys. 2020.587013
Rhee JJ, Zheng Y, Liu S, Montez-Rath ME, Hamill RJ, Ishida JH, et al
. Glycemic Control and Infections Among US Hemodialysis Patients With Diabetes Mellitus. Kidney Int Reports 2020;5:1014–25. https://doi.org/10.1016/j.ekir. 2020.04.020
Gilbert RE, Caldwell L, Misra PS, Chan K, Burns KD, Wrana JL, et al
. Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019. Can J Diabetes 2021;45:162-166.e1. https://doi.org/10.1016/j.jcjd. 20200.07.003
Haarhaus M, Santos C, Haase M, Mota Veiga P, Lucas C, Macario F. Risk prediction of COVID-19 incidence and mortality in a large multi-national hemodialysis cohort: implications for management of the pandemic in outpatient hemodialysis settings. Clin Kidney J 2021;14:805–13. https://doi.org/10.1093/ckj/sfab037
Soleymanian T, Kokabeh Z, Ramaghi R, Mahjoub A, Argani H. Clinical outcomes and quality of life in hemodialysis diabetic patients versus non-diabetics. J Nephropathol 2017;6:81–9. https://doi.org/10.15171/jnp. 2017.14
Seidel M, Hölzer B, Appel H, Babel N, Westhoff TH, Pfab T, et al
. Impact of renal disease and comorbidities on mortality in hemodialysis patients with COVID-19: a multicenter experience from Germany. J Nephrol 2020;33:871–4. https://doi.org/10.1007/s40620-020-00828-8
Glenn DA, Hegde A, Kotzen E, Walter EB, Kshirsagar AV., Falk R, et al
. Systematic review of safety and efficacy of COVID-19 vaccines in patients with kidney disease. Kidney Int Reports 2021;6:1407–10. https://doi.org/10.1016/j.ekir. 20210.02.011
[Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5]
[Table 1], [Table 2]