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ABO-incompatible kidney transplantation in India: A single-center experience of first hundred cases

1 Department of Nephrology, Medanta – The Medicity, Sector 38, Gurugram, Haryana, India
2 Department of Nephrology, Max Super Specialty Hospital, Vaishali, Ghaziabad, Uttar Pradesh, India
3 Department of Urology, Medanta Institute of Kidney and Urology, Gurugram, Haryana, India

Correspondence Address:
Pranaw Kumar Jha,
Department of Nephrology, Medanta – The Medicity, Sector-38, Gurugram, Haryana- 122 001
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijn.IJN_465_20

Aim: ABO-incompatible (ABOi) kidney transplantation overcomes immunological barrier of blood group incompatibility. There have been very few published experiences of ABOi kidney transplantation from India. We present our single-center experience of the first hundred ABOi kidney transplants. Material and Methods: This is a single-center retrospective study of consecutive first hundred ABOi kidney transplant with at least 6 months of follow-up. Results: During the study period (2011–2020), a total of 121 ABOi kidney transplants were performed. Of these, first hundred patients were analyzed. Median follow-up duration was 33 (10–101) months. Mean recipient and donor age were 41.5 ± 13 and 47.68 ± 11.25 years, respectively. Mean HLA mismatch was 4 ± 1.5. Median baseline anti-blood group antibody titer was 128 (2–1024). Most common recipient blood group was O. Patient and death censored graft survival was 93% and 94%, respectively, at median follow-up of 33 months. Biopsy-proven acute rejection (BPAR) rate was 17% with acute antibody-mediated rejection being 3%. Rate of infection was 37%, most common being urinary tract infection. Conclusion: ABOi kidney transplant patients had acceptable patient and graft survival as well as BPAR rates. With current preconditioning protocol, infection rate was high.

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Indian Journal of Nephrology
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