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Year : 2017  |  Volume : 27  |  Issue : 3  |  Page : 231--233

Acute ciprofloxacin-induced crystal nephropathy with granulomatous interstitial nephritis

R Goli1, KK Mukku1, SB Raju1, MS Uppin2 
1 Department of Nephrology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India
2 Department of Pathology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India

Correspondence Address:
S B Raju
Department of Nephrology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad - 500 082, Telangana
India

Crystal-induced acute kidney injury (AKI) is caused by the intratubular precipitation of crystals, which results in obstruction and kidney injury. Ciprofloxacin, a commonly used antibiotic, causes AKI secondary to immune-mediated interstitial injury. Rare mechanisms of ciprofloxacin-induced renal injury include crystalluria, rhabdomyolysis, and granulomatous interstitial nephritis. Clinical and experimental studies have suggested that crystalluria and crystal nephropathy due to ciprofloxacin occur in alkaline urine. Preexisting kidney function impairment, high dose of the medication, and advanced age predispose to this complication. We report a case of ciprofloxacin-induced crystal nephropathy and granulomatous interstitial nephritis in a young patient with no other predisposing factors. The patient responded to conservative treatment without the need for glucocorticoids.

How to cite this article:
Goli R, Mukku K K, Raju S B, Uppin M S. Acute ciprofloxacin-induced crystal nephropathy with granulomatous interstitial nephritis.Indian J Nephrol 2017;27:231-233

How to cite this URL:
Goli R, Mukku K K, Raju S B, Uppin M S. Acute ciprofloxacin-induced crystal nephropathy with granulomatous interstitial nephritis. Indian J Nephrol [serial online] 2017 [cited 2022 Oct 6 ];27:231-233
Available from: https://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2017;volume=27;issue=3;spage=231;epage=233;aulast=Goli;type=0